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TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Study Purpose

The purpose of the study is to learn from the real world practice of prescribing targeted therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be a drug target or to predict sensitivity to a drug. NOTE: Due to character limits, the arms section does NOT include all TAPUR Study relevant biomarkers. For additional information, contact TAPUR@asco.org, or if a patient, your nearest participating TAPUR site (see participating centers). ******************************************************************** Results in publication or poster presentation format are posted as they become available for individual cohorts at www.tapur.org/news. The results may be accessed at any time. All results will be made available on clinicaltrials.gov at the end of the study. Indexing of available results on PubMed is in progress. ********************************************************************

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

 No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

 Interventional
Eligible Ages 12 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - 12 years of age or older (*Restrictions apply.
Not all therapies are available for patients <18)
  • - Histologically-proven locally advanced or metastatic solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma who is no longer benefiting from standard anti-cancer treatment or for whom, in the opinion of the treating physician, no such treatment is available or indicated.
  • - Performance status 0-2 (Per Eastern Cooperative Oncology Group (ECOG) criteria) - Patients must have acceptable organ function as defined below.
However, as noted above, drug-specific inclusion/exclusion criteria specified in the protocol appendix for each agent will take precedence for this and all

inclusion criteria:

1. Absolute neutrophil count ≥ 1.5 x 106/µl. 2. Hemoglobin > 9.0 g/dl. 3. Platelets > 75,000/µl. 4. Total bilirubin < 2.0 mg/ dl, except in patients with Gilbert's Syndrome. 5. Aspartate aminotransferase (AST) serum glutamic-oxaloacetic transaminase (SGOT) and alanine aminotransferase (ALT) serum glutamic-pyruvic transaminase (SGPT) < 2.5 x institutional upper limit of normal (ULN) (or < 5 x ULN in patients with known hepatic metastases) 6. Serum creatinine ≤ 1.5 × ULN or calculated or measured creatinine clearance ≥ 50 mL/min/1.73 m2.
  • - Patients must have disease that can be objectively measured by physical or radiographic exam (per RECIST v1.1 for solid tumor, Lugano criteria for non-Hodgkin lymphoma or International Myeloma Working Group criteria for multiple myeloma), defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as ≥20 mm with conventional techniques or as ≥10 mm with spiral CT scan, MRI, or a subcutaneous or superficial lesion that can be measured with calipers by clinical exam.
For lymph nodes, the short axis must be ≥15 mm. Patient's whose disease cannot be objectively measured by physical or radiographic examination (e.g., elevated serum tumor marker only, bone-only disease without an identifiable soft tissue component, or patients with only assessable non-measurable disease) are NOT eligible.
  • - Results must be available from a genomic test or immunohistochemistry (IHC) test for protein expression performed in a Clinical Laboratory Improvement Amendments (CLIA)-certified and College of American Pathologists (CAP)-accredited or New York State accredited (for labs offering services to residents of NY) laboratory.
Labs that have registered the test with the NIH Genetic Testing Registry or that provide a report that has been designated as optimized for TAPUR participation are preferred, but not required. The genomic or IHC test used to qualify a patient for participation in TAPUR may have been performed on any specimen of the patient's tumor obtained at any point during the patient's care at the discretion of the patient's treating physician. Genomic assays performed on cell-free DNA in plasma ("liquid biopsies") will also be acceptable if the genomic analysis is performed in a laboratory that meets the criteria described above.
  • - Ability to understand and the willingness to sign a written informed consent/assent document.
  • - Have a tumor genomic profile for which single agent treatment with one of the FDA approved targeted anti-cancer drugs included in this study has potential clinical benefit based on the criteria described in protocol.
  • - For orally administered drugs, the patient must be able to swallow and tolerate oral medication and must have no known malabsorption syndrome.
  • - Because of the risks of drug treatment to the developing fetus, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) for the duration of study participation, and for four months following completion of study therapy.
Should a woman become pregnant or suspect she is pregnant while participating in this study or if she is the partner of a male participant in this study and becomes pregnant while he is participating in this study, she should inform her or her partner's treating physician immediately as well as her obstetrician. Female study patients who become pregnant must immediately discontinue treatment with any study therapy. Male patients should avoid impregnating a female partner. Male study patients, even if surgically sterilized, (i.e. post-vasectomy) must agree to one of the following: practice effective barrier contraception during the entire study treatment period and for a specified amount of time the last dose of study drug, or completely abstain from sexual intercourse. Note: TAPUR does not explicitly exclude any type of solid tumor, but the patient must have measurable and evaluable disease per RECIST v1.1.

Exclusion Criteria:

  • - Patients whose disease is not measurable or cannot be assessed by radiographic imaging or physical examination (e.g., elevated serum tumor marker only) are not eligible.
  • - Patients with primary brain tumors or leptomeningeal metastases are excluded.
  • - Patients with previously treated brain metastases are eligible, provided that the patient has not experienced a seizure or had a clinically significant change in neurological status within the 3 months prior to registration.
All patients with previously treated brain metastases must be clinically stable for at least 1 month after completion of treatment and off steroid treatment for one month prior to study enrollment.
  • - Patients with known progressive brain metastases are eligible but additional eligibility criteria apply.
Note: there are additional exclusion criteria that may apply

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

 NCT02693535
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

 Phase 2
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

 American Society of Clinical Oncology
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

 N/A
Principal Investigator Affiliation N/A
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

 Other, Industry
Overall Status Recruiting
Countries United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

 Lymphoma, Non-Hodgkin, Multiple Myeloma, Advanced Solid Tumors
Additional Details

The Targeted Agent and Profiling Utilization Registry (TAPUR) Study is a non-randomized clinical trial that aims to describe the safety and efficacy of commercially available, targeted anticancer drugs prescribed for treatment of patients with advanced cancer that has a potentially actionable genomic variant. TAPUR will study Food and Drug Administration (FDA)-approved targeted therapies that are contributed by collaborating pharmaceutical companies, catalogue the choice of molecular profiling test by clinical oncologists and develop hypotheses for additional clinical trials.

Arms & Interventions

Arms

Other: Group 4 (CDKN2A, CDK4, CDK6)

Participants receive palbociclib - dosage, frequency and duration per label; acceptable genomic matches include CDKN2A loss or mutation, CDK4, CDK6 amplifications, CDKN2B loss or mutation

Other: Group 5 (CSF1R,PDGFR,VEGFR)

Participants receive sunitinib - dosage, frequency and duration per label; acceptable genomic matches include CSF1R, PDGFR, VEGFR1/2/3, KIT, FLT-3, RET, FGFR1/2/3, VHL amplifications or mutations

Other: Group 6 (mTOR, TSC)

Participants receive temsirolimus - dosage, frequency and duration per label; acceptable genomic matches include mTOR, TSC1/2, AKT1 mutations

Other: Group 8 (ERBB2)

Participants receive trastuzumab and pertuzumab - dosage, frequency and duration per label; acceptable genomic matches include ERBB2 amplification or overexpression, and specific ERBB2 mutations

Other: Group 9 (BRAF V600E/D/K/R)

Participants receive vemurafenib and cobimetinib - dosage, frequency and duration per label; acceptable genomic matches include BRAF V600E/D/K/R mutations

Other: Group 13 (RET,VEGFR1/2/3,KIT,PDGFRβ,RAF-1,BRAF)

Participants receive regorafenib - dosage, frequency and duration per label; acceptable genomic matches include RET, VEGFR1/2/3, KIT, PDGFRβ, RAF-1, BRAF mutations or amplifications

Other: Group 14 (BRCA1/2; ATM)

Participants receive olaparib - dosage, frequency and duration per label; acceptable genomic matches include germline or somatic BRCA1/2 inactivating mutations; ATM mutations or deletions

Other: Group 15 (POLE, POLD1)

Participants receive pembrolizumab - dosage, frequency and duration per label; acceptable genomic matches include specific POLE and POLD1 mutations

Other: Group 16 (MSI-H, high mutational load and others)

Participants receive nivolumab and ipilimumab - dosage, frequency and duration per label; acceptable genomic matches include MSI high status, high tumor mutational burden, MLH1, MSH2/6, PMS2, EPCAM mutations, specific POLE or POLD1 mutations, BRCA1/2, ATM, MSH3, PMS1, MLH3, EXO1, RFC1/2/3/4/5, PCNA, RPA1/2/3/4, and SSBP1 loss of function mutations

Other: Group 17 (CDKN2A, CDK4, CDK6)

Participants receive abemaciclib - dosage, frequency and duration per label; acceptable genomic matches include CDKN2A loss or mutation, CDK4, CDK6 amplifications, CDKN2B loss or mutation

Other: Group 19 (BRCA1/2, PALB2)

Participants receive talazoparib - dosage, frequency and duration per label; acceptable genomic matches include germline or somatic BRCA1/2 and PALB2 mutations

Other: Group 20 (ERBB2)

Participants receive atezolizumab plus PHESGO - dosage, frequency and duration per label; acceptable genomic matches include ERBB2 amplification or overexpression

Other: Group 21 (BRCA1/2, PALB2, ATM, and others)

Participants receive atezolizumab plus talazoparib - dosage, frequency and duration per label; acceptable genomic matches include germline or somatic mutations in BRCA1/2, PALB2, ATM, ATR, CHEK2, FANCA, RAD51C, NBN, MLH1, MRE11A, CDK12; positive genomic instability score reported on the Myriad MyChoice CDx test; or Genomic Loss of Heterozygosity (LOH) Score above threshold as reported on a FoundationOne CDx test or another qualifying test for TAPUR with MTB approval

Other: Group 22 (ROS1 fusion)

Participants receive entrectinib - dosage, frequency and duration per label; acceptable genomic matches include any ROS1 fusion

Other: Group 23 (NTRK amplification)

Participants receive larotrectinib - dosage, frequency and duration per label; acceptable genomic matches include NTRK1/2/3 amplification

Other: Group 24 (ERBB2)

Participants receive tucatinib plus trastuzumab SC - dosage, frequency and duration per label; acceptable genomic matches include ERBB2 amplification or overexpression, and specific ERBB2 mutations

Other: Group 25

Participants receive futibatinib- dosage, frequency and duration per label; acceptable genomic matches include FGFR 1,2,3,4 fusion (or other rearrangement) or mutation

Interventions

Drug: - Palbociclib

drug

Drug: - Sunitinib

drug

Drug: - Temsirolimus

drug

Drug: - Trastuzumab and Pertuzumab

drug

Drug: - Vemurafenib and Cobimetinib

drug

Drug: - Regorafenib

drug

Drug: - Olaparib

drug

Drug: - Pembrolizumab

drug

Drug: - Nivolumab and Ipilimumab

drug

Drug: - Abemaciclib

drug

Drug: - Talazoparib

drug

Drug: - Atezolizumab and PHESGO

drug

Drug: - Atezolizumab and Talazoparib

drug

Drug: - Entrectinib

drug

Drug: - Larotrectinib

drug

Drug: - Tucatinib plus Trastuzumab Subcutaneous (SC)

drug

Drug: - Futibatinib

drug

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Birmingham, Alabama

Status

Recruiting

Address

University of Alabama at Birmingham Comprehensive Cancer Center

Birmingham, Alabama, 35294

Site Contact

Misty Lowery

mmlowery@uabmc.edu

205-644-2573

Phoenix, Arizona

Status

Recruiting

Address

Cancer Treatment Centers of America-Phoenix

Phoenix, Arizona, 85338

Site Contact

Russell Fernandez

russell.fernandez@ctca-hope.com

623-207-3126

Sutter Auburn, Auburn, California

Status

Recruiting

Address

Sutter Auburn

Auburn, California, 95602

Site Contact

Kirsten Babski

BabskiK@sutterhealth.org

916-878-4990

Sutter Alta Bates, Berkeley, California

Status

Recruiting

Address

Sutter Alta Bates

Berkeley, California, 94705

Site Contact

Christopher Tang

Christopher.Tang@sutterhealth.org

510-204-3428

Los Angeles, California

Status

Recruiting

Address

The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate

Los Angeles, California, 90025

Site Contact

Saba Mukarram

smukarram@theangelesclinic.org

310-231-2181

Oakland, California

Status

Recruiting

Address

Kaiser Permanente - Oakland Medical Center

Oakland, California, 94611

Site Contact

Desiree Goldstein

desiree.goldstein@kp.org

www.tapur.org

Palo Alto, California

Status

Recruiting

Address

Sutter Palo Alto Medical Foundation: Palo Alto

Palo Alto, California, 94301

Roseville, California

Status

Recruiting

Address

Kaiser Permanente - Roseville Medical Center

Roseville, California, 95661

Site Contact

Desiree Goldstein

desiree.goldstein@kp.org

www.tapur.org

Sutter Roseville, Roseville, California

Status

Recruiting

Address

Sutter Roseville

Roseville, California, 95661

Site Contact

Kirsten Babski

BabskiK@sutterhealth.org

916-878-4990

Sacramento, California

Status

Recruiting

Address

Kaiser Permanente - Sacramento Medical Center

Sacramento, California, 95814

Site Contact

Desiree Goldstein

desiree.goldstein@kp.org

www.tapur.org

Sutter Sacramento, Sacramento, California

Status

Recruiting

Address

Sutter Sacramento

Sacramento, California, 95816

San Francisco, California

Status

Recruiting

Address

Kaiser Permanente - South San Francisco Medical Center

San Francisco, California, 94080

Site Contact

Desiree Goldstein

desiree.goldstein@kp.org

www.tapur.org

San Francisco, California

Status

Recruiting

Address

California Pacific Medical Center Research Institute

San Francisco, California, 94115

San Francisco, California

Status

Recruiting

Address

Kaiser Permanente - San Francisco Medical Center

San Francisco, California, 94115

Site Contact

Desiree Goldstein

desiree.goldstein@kp.org

www.tapur.org

Sutter Cancer Research Consortium, San Francisco, California

Status

Recruiting

Address

Sutter Cancer Research Consortium

San Francisco, California, 94115

Site Contact

Laurel Brechtel

BrechtLa@cpmcri.org

415-600-1654

San Jose, California

Status

Recruiting

Address

Kaiser Permanente - San Jose Medical Center

San Jose, California, 95119

Site Contact

Desiree Goldstein

desiree.goldstein@kp.org

www.tapur.org

San Leandro, California

Status

Recruiting

Address

Kaiser Permanente - San Leandro Medical Center

San Leandro, California, 94577

Site Contact

Desiree Goldstein

desiree.goldstein@kp.org

www.tapur.org

Santa Clara, California

Status

Recruiting

Address

Kaiser Permanente - Santa Clara Medical Center

Santa Clara, California, 95051

Site Contact

Desiree Goldstein

desiree.goldstein@kp.org

www.tapur.org

Santa Cruz, California

Status

Recruiting

Address

Sutter Palo Alto Medical Foundation: Santa Cruz

Santa Cruz, California, 95065

Santa Cruz, California

Status

Recruiting

Address

Sutter Palo Alto Medical Foundation: Fremont

Santa Cruz, California, 994538

Sunnyvale, California

Status

Recruiting

Address

Sutter Palo Alto Medical Foundation: Sunnyvale

Sunnyvale, California, 94086

Vallejo, California

Status

Recruiting

Address

Kaiser Permanente - Vallejo Medical Center

Vallejo, California, 94589

Site Contact

Desiree Goldstein

desiree.goldstein@kp.org

www.tapur.org

Walnut Creek, California

Status

Recruiting

Address

Kaiser Permanente - Walnut Creek Medical Center

Walnut Creek, California, 94596

Site Contact

Desiree Goldstein

desiree.goldstein@kp.org

www.tapur.org

Saint Vincent's Medical Center (SVMC), Bridgeport, Connecticut

Status

Recruiting

Address

Saint Vincent's Medical Center (SVMC)

Bridgeport, Connecticut, 06606

Hartford Hospital, Hartford, Connecticut

Status

Recruiting

Address

Hartford Hospital

Hartford, Connecticut, 06102

Midstate Medical Center (MSMC), Meriden, Connecticut

Status

Recruiting

Address

Midstate Medical Center (MSMC)

Meriden, Connecticut, 06451

New Britain, Connecticut

Status

Recruiting

Address

The Hospital of Central Connecticut (HOCC) Cancer Center

New Britain, Connecticut, 06053

William W. Backus Hospital, Norwich, Connecticut

Status

Recruiting

Address

William W. Backus Hospital

Norwich, Connecticut, 06360

Charlotte Hungerford, Torrington, Connecticut

Status

Recruiting

Address

Charlotte Hungerford

Torrington, Connecticut, 06790

Windham Hospital (WH), Willimantic, Connecticut

Status

Recruiting

Address

Windham Hospital (WH)

Willimantic, Connecticut, 06226

Altamonte Springs, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Altamonte Springs, Florida, 32701

Bonita Springs, Florida

Status

Recruiting

Address

Florida Cancer Specialists South / Sarah Cannon Research Institute

Bonita Springs, Florida, 34135

Bradenton, Florida

Status

Recruiting

Address

Florida Cancer Specialists South / Sarah Cannon Research Institute

Bradenton, Florida, 34211

Brandon, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Brandon, Florida, 33511

Cape Coral, Florida

Status

Recruiting

Address

Florida Cancer Specialists South / Sarah Cannon Research Institute

Cape Coral, Florida, 33909

Clearwater, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Clearwater, Florida, 33761

Daytona Beach, Florida

Status

Recruiting

Address

Florida Cancer Specialists East / Sarah Cannon Research Institute

Daytona Beach, Florida, 32117

Fleming Island, Florida

Status

Recruiting

Address

Florida Cancer Specialists Panhandle / Sarah Cannon Research Institute

Fleming Island, Florida, 32003

Holy Cross Hospital, Fort Lauderdale, Florida

Status

Recruiting

Address

Holy Cross Hospital

Fort Lauderdale, Florida, 33308

Fort Myers, Florida

Status

Recruiting

Address

Florida Cancer Specialists South / Sarah Cannon Research Institute

Fort Myers, Florida, 33901

Fort Myers, Florida

Status

Recruiting

Address

Florida Cancer Specialists South / Sarah Cannon Research Institute

Fort Myers, Florida, 33905

Fort Myers, Florida

Status

Recruiting

Address

Florida Cancer Specialists South / Sarah Cannon Research Institute

Fort Myers, Florida, 33908

Gainesville, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Gainesville, Florida, 32605

University of Florida Health, Gainesville, Florida

Status

Recruiting

Address

University of Florida Health

Gainesville, Florida, 32610

Site Contact

Nghi Lam, MS

Nghi.Lam@cancer.ufl.edu

352-265-5329

Largo, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Largo, Florida, 33770

Lecanto, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Lecanto, Florida, 34461

Miami, Florida

Status

Recruiting

Address

University of Miami Sylvester Comprehensive Cancer Center

Miami, Florida, 33136

Site Contact

Carolina Troche, BS

cxt582@med.miami.edu

305-243-1481

Naples, Florida

Status

Recruiting

Address

Florida Cancer Specialists South / Sarah Cannon Research Institute

Naples, Florida, 34102

Ocala, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Ocala, Florida, 34474

Orange City, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Orange City, Florida, 32763

Orlando, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Orlando, Florida, 32806

Port Charlotte, Florida

Status

Recruiting

Address

Florida Cancer Specialists South / Sarah Cannon Research Institute

Port Charlotte, Florida, 33980

Saint Petersburg, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Saint Petersburg, Florida, 33705

Sarasota, Florida

Status

Recruiting

Address

Florida Cancer Specialists South / Sarah Cannon Research Institute

Sarasota, Florida, 34232

Sarasota, Florida

Status

Recruiting

Address

Florida Cancer Specialists South / Sarah Cannon Research Institute

Sarasota, Florida, 34236

Stuart, Florida

Status

Recruiting

Address

Florida Cancer Specialists East / Sarah Cannon Research Institute

Stuart, Florida, 34994

Tallahassee, Florida

Status

Recruiting

Address

Florida Cancer Specialists Panhandle / Sarah Cannon Research Institute

Tallahassee, Florida, 32308

Tampa, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Tampa, Florida, 33607

Tavares, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Tavares, Florida, 32778

The Villages, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

The Villages, Florida, 32159

Trinity, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Trinity, Florida, 34655

Venice, Florida

Status

Recruiting

Address

Florida Cancer Specialists South / Sarah Cannon Research Institute

Venice, Florida, 34285

Venice, Florida

Status

Recruiting

Address

Florida Cancer Specialists South / Sarah Cannon Research Institute

Venice, Florida, 34292

Vero Beach, Florida

Status

Recruiting

Address

Florida Cancer Specialists East / Sarah Cannon Research Institute

Vero Beach, Florida, 32960

Wellington, Florida

Status

Recruiting

Address

Florida Cancer Specialists East / Sarah Cannon Research Institute

Wellington, Florida, 33414

West Palm Beach, Florida

Status

Recruiting

Address

Florida Cancer Specialists East / Sarah Cannon Research Institute

West Palm Beach, Florida, 33401

Winter Park, Florida

Status

Recruiting

Address

Florida Cancer Specialists North / Sarah Cannon Research Institute

Winter Park, Florida, 32789

Atlanta, Georgia

Status

Recruiting

Address

Cancer Treatment Centers of America - Atlanta

Atlanta, Georgia, 30265

Site Contact

Celeste Barker, CCRC

celeste.barker@coh.org

470-241-7346

Atlanta, Georgia

Status

Recruiting

Address

Emory University Winship Cancer Institute

Atlanta, Georgia, 30322

Site Contact

Suzanne Scott

suzanne.e.scott@emory.edu

404-778-4083

Savannah, Georgia

Status

Recruiting

Address

Gynecologic Oncology and Surgical Specialists at the Lewis Cancer & Research Pavilion

Savannah, Georgia, 31405

Site Contact

Stephanie Smith, RN, MSN, OCN

smiths1@sjchs.org

912-819-5723

Savannah, Georgia

Status

Recruiting

Address

Lewis Cancer & Research Pavilion at the Melanoma, Skin Cancer & Sarcoma Institute

Savannah, Georgia, 31405

Site Contact

Stephanie Smith, RN, MSN, OCN

smiths1@sjchs.org

912-819-5723

Lewis Cancer & Research Pavilion, Savannah, Georgia

Status

Recruiting

Address

Lewis Cancer & Research Pavilion

Savannah, Georgia, 31405

Site Contact

Stephanie Smith, RN, MSN, OCN

smiths1@sjchs.org

912-819-5723

Summit Cancer Care, Savannah, Georgia

Status

Recruiting

Address

Summit Cancer Care

Savannah, Georgia, 31405

Site Contact

Stephanie Smith, RN, MSN, OCN

smiths1@sjchs.org

912-819-5723

Honolulu, Hawaii

Status

Active, not recruiting

Address

The Queen's Medical Center (The University of Texas MD Anderson Cancer Center)

Honolulu, Hawaii, 96813

Chicago, Illinois

Status

Recruiting

Address

Cancer Treatment Centers of America-Chicago

Chicago, Illinois, 60099

Site Contact

Office of Clinical Trials

mrmcresearch@ctca-hope.ocm

847-731-1777

Indianapolis, Indiana

Status

Recruiting

Address

Community Health Network (The University of Texas MD Anderson Cancer Center)

Indianapolis, Indiana, 46250

Site Contact

Amanda Eckert, MPH

ACEckert@mdanderson.org

713-745-8074

Harold Alfond Center for Cancer Care, Augusta, Maine

Status

Recruiting

Address

Harold Alfond Center for Cancer Care

Augusta, Maine, 04330

Site Contact

Sandra Neptune, BSN, RN

sandra.neptune@mainegeneral.org

207-626-4811

Augusta, Maine

Status

Recruiting

Address

Jackson Laboratory - Maine Cancer Genomics Initiative

Augusta, Maine, 04330

Site Contact

Petra Helbig, CCRP

Petra.Helbig@jax.org

207-664-4659

Waldo County General Hospital, Belfast, Maine

Status

Recruiting

Address

Waldo County General Hospital

Belfast, Maine, 04915

Site Contact

Jen Dalton, MHA, BSN, RN

JDalton@mmc.org

207-294-8291

Biddeford, Maine

Status

Recruiting

Address

SMHC Cancer Care and Blood Disorders -Biddeford

Biddeford, Maine, 04005

Site Contact

Jen Dalton

JDalton@mmc.org

207-294-8291

Northern Light Cancer Care, Brewer, Maine

Status

Recruiting

Address

Northern Light Cancer Care

Brewer, Maine, 04412

Site Contact

Carla Mancini, MHA, BSN, RN

cmancini@northernlight.org

207-973-5581

Brewer, Maine

Status

Recruiting

Address

Raish Peavey Haskell Children's Cancer and Treatment Center

Brewer, Maine, 04412

Site Contact

Carla C Mancini, RN, BSN, OCN

cmancini@northernlight.org

207-973-5581

MaineHealth Cancer Care -Brunswick, Brunswick, Maine

Status

Recruiting

Address

MaineHealth Cancer Care -Brunswick

Brunswick, Maine, 04011

Site Contact

Jen Dalton, MHA, BSN, RN

JDalton@mmc.org

207-294-8291

New England Cancer Specialist, Kennebunk, Maine

Status

Recruiting

Address

New England Cancer Specialist

Kennebunk, Maine, 04043

Site Contact

Patricia C Collins

collip@newecs.org

207-303-3422

Kittery, Maine

Status

Recruiting

Address

York Hopsital Oncology & Infusion Care in Kittery

Kittery, Maine, 03904

Site Contact

Brenda i Kiberd, RN

Brenda.Kiberd@yorkhospital.com

207-361-6115

Stephens Memorial Hospital, Norway, Maine

Status

Recruiting

Address

Stephens Memorial Hospital

Norway, Maine, 04268

Site Contact

Jen Dalton, MHA, BSN, RN

JDalton@mmc.org

207-294-8291

Penobscot Bay Medical Center, Rockport, Maine

Status

Recruiting

Address

Penobscot Bay Medical Center

Rockport, Maine, 04856

Site Contact

Jen Dalton, MHA, BSN, RN

JDalton@mmc.org

207-294-8291

Sanford, Maine

Status

Recruiting

Address

SMHC Cancer Care and Blood Disorders -Sandford

Sanford, Maine, 04073

Site Contact

Jen Dalton, MHA, BSN, RN

JDalton@mmc.org

207-294-8291

Maine Children's Cancer Program, Scarborough, Maine

Status

Recruiting

Address

Maine Children's Cancer Program

Scarborough, Maine, 04074

Site Contact

Jen Dalton, MHA, BSN, RN

JDalton@mmc.org

207-294-8291

Maine Medical Partner's Women's Health, Scarborough, Maine

Status

Recruiting

Address

Maine Medical Partner's Women's Health

Scarborough, Maine, 04074

Site Contact

Jen Dalton, MHA, BSN, RN

JDalton@mmc.org

207-294-8291

New England Cancer Specialist, Scarborough, Maine

Status

Recruiting

Address

New England Cancer Specialist

Scarborough, Maine, 04074

Site Contact

Patricia Collins, BA, CCRC

collip@newecs.org

207-303-3422

MaineHealth Cancer Care -South Portland, South Portland, Maine

Status

Recruiting

Address

MaineHealth Cancer Care -South Portland

South Portland, Maine, 04106

Site Contact

Jen Dalton, MHA, BSN, RN

JDalton@mmc.org

207-294-8291

New England Cancer Specialist, Topsham, Maine

Status

Recruiting

Address

New England Cancer Specialist

Topsham, Maine, 04086

Site Contact

Patricia C Collins, BA, CCRC

collip@newecs.org

207-303-3422

Wells, Maine

Status

Recruiting

Address

York Hospital Oncology & Infusion Care in Wells

Wells, Maine, 04090

Site Contact

Brenda Kiberd, RN

Brenda.Kiberd@yorkhospital.com

207-361-6115

York, Maine

Status

Recruiting

Address

York Hospital Oncology & Infusion Care in York

York, Maine, 03909

Site Contact

Brenda i Kiberd, RN

Brenda.Kiberd@yorkhospital.com

207-361-6115

Trinity Health Ann Arbor Hospital, Ann Arbor, Michigan

Status

Recruiting

Address

Trinity Health Ann Arbor Hospital

Ann Arbor, Michigan, 48106

University of Michigan, Ann Arbor, Michigan

Status

Recruiting

Address

University of Michigan

Ann Arbor, Michigan, 48109

Site Contact

Cancer AnswerLine Nurses

canceranswerline@med.umich.edu

800-865-1125

Ascension St. John Hospital, Detroit, Michigan

Status

Recruiting

Address

Ascension St. John Hospital

Detroit, Michigan, 48236

Genesys Hurley Cancer Institute, Grand Blanc, Michigan

Status

Recruiting

Address

Genesys Hurley Cancer Institute

Grand Blanc, Michigan, 48439

Grand Rapids, Michigan

Status

Recruiting

Address

Cancer Research Consortium of West Michigan

Grand Rapids, Michigan, 49503

Site Contact

Connie Szczepanek, RN

crcwm-regulatory@crcwm.org

616-391-1230

Sparrow Hospital, Lansing, Michigan

Status

Recruiting

Address

Sparrow Hospital

Lansing, Michigan, 48912

Trinity Health Livonia Hospital, Livonia, Michigan

Status

Recruiting

Address

Trinity Health Livonia Hospital

Livonia, Michigan, 48154

Trinity Health Oakland Hospital, Pontiac, Michigan

Status

Recruiting

Address

Trinity Health Oakland Hospital

Pontiac, Michigan, 48341

Ascension St. Mary's Hospital, Saginaw, Michigan

Status

Recruiting

Address

Ascension St. Mary's Hospital

Saginaw, Michigan, 48601

Michigan Cancer Research Consortium, Traverse City, Michigan

Status

Recruiting

Address

Michigan Cancer Research Consortium

Traverse City, Michigan, 48341

Site Contact

Beth LaVasseur, RN, MS

Beth.LaVasseur@stjoeshealth.org

734-712-7251

St. John Macomb Oakland Hospital, Warren, Michigan

Status

Recruiting

Address

St. John Macomb Oakland Hospital

Warren, Michigan, 48093

University of Nebraska Medical Center, Omaha, Nebraska

Status

Recruiting

Address

University of Nebraska Medical Center

Omaha, Nebraska, 68198

Site Contact

Micki Bethea, BS

mbethea@unmc.edu

402-559-8011

NH Oncology - Hematology, PA, Concord, New Hampshire

Status

Recruiting

Address

NH Oncology - Hematology, PA

Concord, New Hampshire, 03103

Site Contact

Ali Fleury

A.Fleury@nhoh.com

603-314-6888

Solinsky Center for Cancer Care, Manchester, New Hampshire

Status

Recruiting

Address

Solinsky Center for Cancer Care

Manchester, New Hampshire, 03103

Site Contact

Ali Fleury, BA, CCRP

A.Fleury@nhoh.com

603-314-6888

New England Cancer Specialist, Portsmouth, New Hampshire

Status

Recruiting

Address

New England Cancer Specialist

Portsmouth, New Hampshire, 03801

Site Contact

Patricia C Collins, BA, CCRC

collip@newecs.org

207-303-3422

Albuquerque, New Mexico

Status

Recruiting

Address

Lovelace Medical Center - Saint Joseph Square

Albuquerque, New Mexico, 87102

Site Contact

Leslie Byatt

lpbyatt@salud.unm.edu

505-925-0366

Presbyterian Kaseman Hospital, Albuquerque, New Mexico

Status

Recruiting

Address

Presbyterian Kaseman Hospital

Albuquerque, New Mexico, 87110

Site Contact

Monique Robertson, RN

mrobertso2@phs.org

505-559-6100

Albuquerque, New Mexico

Status

Recruiting

Address

The University of New Mexico Comprehensive Cancer Center

Albuquerque, New Mexico, 87131

Site Contact

Kawryn Gustafson, RN

ksgustafson@salud.unm.edu

505-925-0380

Memorial Medical Center, Las Cruces, New Mexico

Status

Recruiting

Address

Memorial Medical Center

Las Cruces, New Mexico, 88011

Site Contact

Kim Hoffman, RN

kim.hoffman@lpnt.net

575-556-6545

Presbyterian Rust Medical Center, Rio Rancho, New Mexico

Status

Recruiting

Address

Presbyterian Rust Medical Center

Rio Rancho, New Mexico, 87124

Site Contact

Andrea Yost

ayost3@phs.org

505-253-7878

Northwell Health Monter Cancer Center, Lake Success, New York

Status

Recruiting

Address

Northwell Health Monter Cancer Center

Lake Success, New York, 11042

Site Contact

Mary Agnes Templeton

mtempleton@northwell.edu

516-734-8979

Cohen Children's Medical Center, New Hyde Park, New York

Status

Recruiting

Address

Cohen Children's Medical Center

New Hyde Park, New York, 11040

Site Contact

Shreya Seepersaud

sseepersaud2@northwell.edu

718-470-7146

New York, New York

Status

Recruiting

Address

Herbert Irving Comprehensive Cancer Center

New York, New York, 10032

Site Contact

Kim Roman

Lr2787@cumc.columbia.edu

212-342-3970

Manhattan Eye, Ear, and Throat Hospital, New York, New York

Status

Recruiting

Address

Manhattan Eye, Ear, and Throat Hospital

New York, New York, 10065

Site Contact

Leila Nasr

lnasr@northwell.edu

www.tapur.org

Phelps Hospital, Sleepy Hollow, New York

Status

Recruiting

Address

Phelps Hospital

Sleepy Hollow, New York, 10591

Site Contact

Barbara Turner, RN

Bturner1@northwell.edu

914-269-1949

Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

Status

Recruiting

Address

Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599

Site Contact

Emmie Cole

emmie_cole@med.unc.edu

919-966-4432

Atrium Health's Levine Cancer Institute, Charlotte, North Carolina

Status

Recruiting

Address

Atrium Health's Levine Cancer Institute

Charlotte, North Carolina, 28277

Site Contact

Kelly Bumgarner, RN, CCRP

Kelly.Bumgarner@atriumhealth.org

980-521-8696

Sanford Health- Bismarck, Bismarck, North Dakota

Status

Recruiting

Address

Sanford Health- Bismarck

Bismarck, North Dakota, 58501

Site Contact

Peter Kurniali, MD

peter.kurniali@sanfordhealth.org

701-323-5741

Sanford Health- Fargo, Fargo, North Dakota

Status

Recruiting

Address

Sanford Health- Fargo

Fargo, North Dakota, 58122

Site Contact

Anu Gaba, MD

anu.gaba@sanfordhealth.org

701-234-6161

University of Cincinnati Medical Center, Cincinnati, Ohio

Status

Recruiting

Address

University of Cincinnati Medical Center

Cincinnati, Ohio, 45219

Site Contact

Kayla Webb, MSN, RN

webb2ka@ucmail.uc.edu

513-584-0599

Kettering Health, Kettering, Ohio

Status

Recruiting

Address

Kettering Health

Kettering, Ohio, 45429

Site Contact

Allison Dymacek, BSN, RN

allison.dymacek@ketteringhealth.org

937-395-8367

West Chester Hospital, West Chester, Ohio

Status

Recruiting

Address

West Chester Hospital

West Chester, Ohio, 45069

Site Contact

Kayla Webb, MSN, RN

webb2ka@ucmail.uc.edu

513-584-0599

Providence Health & Services, Portland, Oregon

Status

Recruiting

Address

Providence Health & Services

Portland, Oregon, 97213

Site Contact

Isa Ngirailemesang

Isa.Ngirailemesang@providence.org

971-358-2056

Lehigh Valley Health Network, Allentown, Pennsylvania

Status

Recruiting

Address

Lehigh Valley Health Network

Allentown, Pennsylvania, 18103

Lehigh Valley Hospital- Muhlenberg, Bethlehem, Pennsylvania

Status

Recruiting

Address

Lehigh Valley Hospital- Muhlenberg

Bethlehem, Pennsylvania, 18017

Pocono Medical Center, East Stroudsburg, Pennsylvania

Status

Recruiting

Address

Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301

Lehigh Valley Hospital-Hazleton, Hazleton, Pennsylvania

Status

Recruiting

Address

Lehigh Valley Hospital-Hazleton

Hazleton, Pennsylvania, 18201

Fox Chase Cancer Center, Philadelphia, Pennsylvania

Status

Recruiting

Address

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111

Site Contact

Fathima S Sheriff

fathima.sheriff@fccc.edu

215-728-4094

Bluffton, South Carolina

Status

Recruiting

Address

SC Cancer Specialists at St. Joseph's/Candler Bluffton

Bluffton, South Carolina, 29910

Site Contact

Stephanie Smith, RN, MSN, OCN

smiths1@sjchs.org

912-819-5723

St. Joseph's/Candler Smith, Bluffton, South Carolina

Status

Recruiting

Address

St. Joseph's/Candler Smith

Bluffton, South Carolina, 29910

Site Contact

Stephanie Smith, RN, MSN, OCN

smiths1@sjchs.org

912-819-5723

Bluffton, South Carolina

Status

Recruiting

Address

Summit Cancer Care at St. Josph's/Candler Bluffton

Bluffton, South Carolina, 29910

Site Contact

Stephanie Smith, RN, MSN, OCN

smiths1@sjchs.org

912-819-5723

South Carolina Cancer Specialists, Hilton Head Island, South Carolina

Status

Recruiting

Address

South Carolina Cancer Specialists

Hilton Head Island, South Carolina, 29926

Site Contact

Stephanie Smith, RN, MSN, OCN

smiths1@sjchs.org

912-819-5723

Sioux Falls, South Dakota

Status

Recruiting

Address

Sanford Cancer Center Oncology Clinic and Pharmacy

Sioux Falls, South Dakota, 57104

Site Contact

Steven Powell, MD

steven.powell@sanfordhealth.org

605-328-8000

Nashville, Tennessee

Status

Recruiting

Address

Tennessee Oncology - Nashville / Sarah Cannon Research Institute

Nashville, Tennessee, 37203

Site Contact

Ethan Trull

Ethan.Trull@SarahCannon.com

615-329-7274

Houston, Texas

Status

Recruiting

Address

The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030

Site Contact

Amanda Eckert, MPH

ACEckert@mdanderson.org

713-745-8074

Cedar City, Utah

Status

Recruiting

Address

Cedar City Hospital, SW Cancer Clinic, Sandra Maxwell Cancer Center

Cedar City, Utah, 84720

Site Contact

Jake Kolu

Jake.Kolu@imail.org

435-705-1632

Saint George, Utah

Status

Recruiting

Address

Dixie Regional Medical Center-River Road Campus

Saint George, Utah, 84770

Site Contact

Jake Kolu

Jake.Kolu@imail.org

435-705-1632

Intermountain Healthcare, Salt Lake City, Utah

Status

Recruiting

Address

Intermountain Healthcare

Salt Lake City, Utah, 84107

Site Contact

Tracy Taylor

tracy.taylor@imail.org

801-507-3953

Inova Schar Cancer Institute, Fairfax, Virginia

Status

Recruiting

Address

Inova Schar Cancer Institute

Fairfax, Virginia, 22042

Site Contact

Roxana Comfort, CRC

roxana.comfort@inova.org

571-472-0628

Swedish Cancer Institute, Seattle, Washington

Status

Recruiting

Address

Swedish Cancer Institute

Seattle, Washington, 98104

Site Contact

Kim Reeves

Kimberly.Reeves@swedish.org

206-337-3851

Aurora Cancer Care - Burlington, Burlington, Wisconsin

Status

Recruiting

Address

Aurora Cancer Care - Burlington

Burlington, Wisconsin, 53105

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Germantown, Wisconsin

Status

Recruiting

Address

Aurora Health Care - Germantown Health Center

Germantown, Wisconsin, 53022

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Aurora Cancer Care - Grafton, Grafton, Wisconsin

Status

Recruiting

Address

Aurora Cancer Care - Grafton

Grafton, Wisconsin, 53024

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Aurora BayCare Medical Center, Green Bay, Wisconsin

Status

Recruiting

Address

Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Aurora Cancer Care - Kenosha South, Kenosha, Wisconsin

Status

Recruiting

Address

Aurora Cancer Care - Kenosha South

Kenosha, Wisconsin, 53142

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Aurora Bay Area Medical Center, Marinette, Wisconsin

Status

Recruiting

Address

Aurora Bay Area Medical Center

Marinette, Wisconsin, 54143

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Aurora Cancer Care Milwaukee, Milwaukee, Wisconsin

Status

Recruiting

Address

Aurora Cancer Care Milwaukee

Milwaukee, Wisconsin, 53209

Site Contact

Michelle M Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Aurora St. Luke's Medical Center, Milwaukee, Wisconsin

Status

Recruiting

Address

Aurora St. Luke's Medical Center

Milwaukee, Wisconsin, 53215

Site Contact

Michelle M Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Aurora Sinai Medical Center, Milwaukee, Wisconsin

Status

Recruiting

Address

Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53223

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Aurora West Allis Medical Center, Milwaukee, Wisconsin

Status

Recruiting

Address

Aurora West Allis Medical Center

Milwaukee, Wisconsin, 53227

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin

Status

Recruiting

Address

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Aurora Cancer Care - Racine, Racine, Wisconsin

Status

Recruiting

Address

Aurora Cancer Care - Racine

Racine, Wisconsin, 53406

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Vince Lombardi Cancer Center, Sheboygan, Wisconsin

Status

Recruiting

Address

Vince Lombardi Cancer Center

Sheboygan, Wisconsin, 53081

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Aurora Medical Center in Summit, Summit, Wisconsin

Status

Recruiting

Address

Aurora Medical Center in Summit

Summit, Wisconsin, 53066

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Two Rivers, Wisconsin

Status

Recruiting

Address

Vince Lombardi Cancer Clinic - Two Rivers

Two Rivers, Wisconsin, 54241

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

Aurora Cancer Care - Milwaukee West, Wauwatosa, Wisconsin

Status

Recruiting

Address

Aurora Cancer Care - Milwaukee West

Wauwatosa, Wisconsin, 53226

Site Contact

Michelle Toutloff, RN, CCRP

Michelle.Martin2@aah.org

920-456-7880

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