Inclusion Criteria:
1. Male or female patients 18 years or older.
2. Voluntary written consent must be given before performance of any study related
procedure not part of standard medical care, with the understanding that consent may
be withdrawn by the patient at any time without prejudice to future medical care.
3. Life expectancy > 3 months.
4. Eastern Cooperative Oncology Group (ECOG) performance status and/or other performance
status 0, 1, or 2.
5. Presence
- - at diagnosis or at relapse - of one of the following adverse genomic
abnormalities determined using Interphase fluorescence in situ hybridization and
Single nucleotide polymorphism (FISH/SNP) techniques at a significant rate validated
centrally by Pr AVET - LOISEAU:
- deletion 17p.
- - and/ or translocation (4; 14)
6.
Must have an RRMM and have received a Lenalidomide line of treatment. 7. Must have a Progressive Multiple Myeloma (MM) according to IMWG consensus
recommendations for multiple myeloma treatment response criteria (DURIE 2007, RAJKUMAR
2011) :
- - Increase of 25% from lowest response value in any one of the following:
- Serum M-component (absolute increase must be ≥ 0.5 g/dL),
- Urine M-component (absolute increase must be ≥ 200 mg/24 hours),
- Only in subjects without measurable serum and urine M-protein levels: the
difference between involved and uninvolved FLC (Free Light-Chain) levels
(absolute increase must be >10 mg/dL)
- Bone marrow plasma cell percentage: the absolute percentage must be >10%
- Definite development of new bone lesions or soft tissue plasmacytomas or definite
increase in the size of existing bone lesions or soft tissue plasmacytomas.
- - Development of hypercalcemia (corrected serum calcium >11.5 mg/dL) that can be
attributed solely to the PC (Plasma Cell) proliferative disorder.
8. Must have a measurable disease as defined by the following:
- - IgG (immunoglobulin G) and IgA (immunoglobulin A) (serum M-component > 5g/l)
- IgD (immunoglobulin D) (serum M-component > 0.5g/l)
- Light chain (Bence Jones > 200mg/24h)
- For MM without measurable serum or urine M protein, involved FLC ≥100 mg/l and
FLC abnormal ratio.
9. Patients must meet the following clinical laboratory criteria:
- - Absolute neutrophil count (ANC) ≥ 1,000/mm3 and platelet count ≥ 75,000/mm3.
Platelet transfusions to help patients meet eligibility criteria are not allowed
within 3 days before study enrollment.
- - Total bilirubin ≤1.5 x the upper limit of the normal range (ULN).
- - Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3 x ULN.
- - Calculated creatinine clearance ≥ 30 mL/min MDRD (Modification of Diet in Renal
Disease) formula should be used for calculating creatinine clearance values:
http://mdrd.
com/
10. Able to undergo antithrombotic prophylactic treatment. HBPM (low weight heparin) is
preferred. In case of anti-Vitamin K Agent, INR (international normalized ratio) must
be used. 11. Female patients who:
- - Have been postmenopausal for at least 2 years before the screening visit, OR.
- - Are surgically sterile, OR.
- - If they are of childbearing potential, agree to practice 2 effective methods of
contraception, at the same time, from the time of signing the informed consent
form through 90 days after the last dose of study drug, OR.
- - Agree to practice true abstinence when this is in line with the preferred and
usual lifestyle of the subject.
(Periodic abstinence [e.g., calendar, ovulation,
symptothermal and post-ovulation methods] and withdrawal are not acceptable
methods of contraception.)
Male patients, even if surgically sterilized (i.e., status post-vasectomy), must agree
to one of the following:
- - Agree to practice effective barrier contraception during the entire study
treatment period and through 90 days after the last dose of study drug, OR.
- - Agree to practice true abstinence when this is in line with the preferred and
usual lifestyle of the subject.
(Periodic abstinence [e.g., calendar, ovulation,
symptothermal and post-ovulation methods] and withdrawal are not acceptable
methods of contraception.)
12. Patients agree:
- - not to share study medication with any other person and to return all unused
study drugs to the investigator.
- - to abstain from donating blood while taking the study drug therapy and for one
week following discontinuation of the study drug therapy.
13. Must be able to adhere to the study visit schedule and other protocol requirements
including the pregnancy prevention program as detailed in section 13.4 of protocol. 14. Affiliated with an appropriate social security system.
Exclusion Criteria:
1. Any other uncontrolled medical condition or comorbidity that might interfere with
subject's participation.
2. Patients not having receive Lenalidomide. 3. Pregnant or breast feeding females. 4. Known positive for HIV or active hepatitis type B or C.
5. Patients with non-secretory MM. 6. Patient with terminal renal failure that require dialysis and clearance creatinine <
30ml/min. 7. Prior history of malignancies, other than multiple myeloma, unless the patients has
been free of the disease for ≥ 5 years.
8. Prior local irradiation within two weeks before first dose*
*However, an exception (that is patients allowed to remain in the treatment phase of
the study) is made for radiation therapy to a pathological fracture site to enhance
bone healing or to treat post-fracture pain that is refractory to narcotic analgesics
because pathologic bone fractures do not by themselves fulfill a criterion for disease
progression.)
9. Evidence of central nervous system (CNS) involvement. 10. Unable to take corticotherapy at study entry, Ixazomib or pomalidomide. 11. Infection requiring systemic antibiotic therapy or other serious infection within 14
days before study enrollment. 12. Ongoing Cardiac dysfunction: specify e.g. uncontrolled hypertension, MI (Myocardial
Infarction) within 6 months, unstable Angina pectoris, Cardiac arrhythmia Grade 2 or
higher. 13. Patients planned to receive a transplantation while on IPd protocol. 14. Patients who have had Ixazomib and Pomalidomide therapy as a previous line. 15. Participation in other clinical trials, including those with other investigational
agents not included in this trial, within 30 days of the start of this trial and
throughout the duration of this trial.
16. Failure to have fully recovered (ie, ≤ Grade 1 toxicity) from the reversible effects
of prior chemotherapy.
17. Inability or unwillingness to comply with birth control requirements. 18. Unable to take antithrombotic medicines at study entry. 19. Major surgery within 14 days before enrollment.
20. Systemic treatment, within 14 days before the first dose of ixazomib and Pomalidomide,
with strong CYP3A (Cytochrome P450 3A) inducers (rifampicin, rifapentine, rifabutin,
carbamazepine, phenytoin, phenobarbital), or use of St. John's wort.
21. Any serious medical or psychiatric illness that could, in the investigator's opinion,
potentially interfere with the completion of treatment according to this protocol.
22. Known allergy to any of the study medications, their analogues, or excipients in the
various formulations of any agent.
23. Known GI disease or GI procedure that could interfere with the oral absorption or
tolerance of ixazomib and Pomalidomide including difficulty swallowing.
24. Patient has ≥ Grade 3 peripheral neuropathy, or Grade 2 with pain on clinical
examination during the screening period.
25. Patients that have previously been treated with ixazomib, or participated in a study
with ixazomib whether treated with ixazomib or not.
26. Subjects under juridical protection guardianship or tutelage measure
