Venetoclax and Tocilizumab for the Treatment of Patients With Relapsed or Refractory t(11;14) Multiple Myeloma

Study Purpose

This phase I trial finds out the best dose and side effects of venetoclax and tocilizumab in treating patients with t(11;14) multiple myeloma that has come back (relapsed) or does not respond to treatment (refractory). Venetoclax may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Tocilizumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Tocilizumab is used to treat side effects from immune therapy in patients with myeloma. Giving venetoclax and tocilizumab may kill more cancer cells.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Subject must be >= 18 years of age.
  • - Subject has an Eastern Cooperative Oncology Group (ECOG) performance score of =< 2.
  • - Diagnosis of multiple myeloma that requires treatment and has been previously treated with: - >= 3 prior line of therapy.
Have received treatment with a proteasome inhibitor, an immunomodulatory (IMiD) agent (e.g., thalidomide, lenalidomide, pomalidomide) and a CD38 monoclonal antibody.
  • - Have MM positive for t(11;14) translocation as determined by an analytically validated fluorescence in-situ hybridization (FISH) assay per the central laboratory testing.
  • - Subject must have had measurable disease at Screening, defined as any of the following: - Serum monoclonal protein >= 1.0 g/dL (>= 10 g/L) by protein electrophoresis, or.
  • - >= 200 mg of monoclonal protein in the urine on 24-hour electrophoresis, or.
  • - Serum immunoglobulin free light chain (FLC) >= 10 mg/dL provided serum FLC ratio is abnormal.
  • - Subjects with a history of autologous transplantation must have adequate peripheral blood counts as defined below, have recovered from any transplant related toxicity(s) and be > 100 days post-autologous transplant (prior to first dose of study drug) - Absolute neutrophil count (ANC) >= 1000/uL (Subject may use granulocyte colony-stimulating factor [G-CSF] to achieve ANC eligibility criteria) - Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 1.5 x upper limit of normal range (ULN) - Calculated creatinine clearance >= 30 mL/min using a modified Cockcroft- Gault calculation or a 24-hour urine collection for creatinine clearance.
  • - Platelet count >= 75,000 cells/mm3 and independent of transfusion for 2 weeks.
  • - Hemoglobin >= 8.0 g/dL, subjects may not receive blood transfusion within 1 week to achieve hemoglobin eligibility criteria per investigator discretion.
  • - Total bilirubin =< 1.5 x ULN; subjects with Gilbert's syndrome may have bilirubin > 1.5 x ULN.
  • - If female, subject must be: - Postmenopausal defined as: - Age > 55 years with no menses for 24 or more months without an alternative medical cause.
  • - Age =< 55 years with no menses for 24 or more months without an alternative medical cause.
  • - AND an follicle stimulating hormone (FSH) level > 40 IU/L.
OR.
  • - Permanently surgical sterile (bilateral oophorectomy, bilateral salpingectomy, or hysterectomy) OR.
  • - A woman of childbearing potential (WOCP) practicing at least one protocol specified method of birth control starting at cycle 1 day 1 (or earlier) through at least 30 days after last dose of study drug.
  • - Females of childbearing potential (must have negative results for pregnancy test performed: - At screening, on a serum or urine sample obtained within 28 days prior to the first study drug administration, - Prior to dosing, on a urine sample obtained on the first day of study drug dosing, if it has been > 7 days since obtaining the serum pregnancy test results.
  • - Females of non-childbearing potential (either postmenopausal or permanently surgically sterile as defined above) at screening do not require pregnancy testing.
  • - Must voluntarily sign and date an informed consent, approved by an Independent Ethics Committee (IEC)/Institutional Review Board (IRB), prior to the initiation of any screening or study-specific procedures.

Exclusion Criteria:

  • - Subject exhibits evidence of other clinically significant uncontrolled condition(s), including, but not limited to: - Acute infection within 14 days prior to first dose of study drug requiring antibiotic, antifungal, or antiviral therapy.
  • - Diagnosis of fever and neutropenia within 1 week prior to first dose of study drug.
  • - Subject has a cardiovascular disability status of New York Heart Association class >= 3.
  • - Subject has a significant history of renal, neurologic, psychiatric, endocrinologic, metabolic, immunologic, cardiovascular or hepatic disease within the last 6 months that, in the opinion of the investigator, would adversely affect his/her participation in the study.
  • - Subject has a history of other active malignancies other than multiple myeloma within the past 3 years prior to study entry, with the following exceptions: - Adequately treated in situ carcinoma of the cervix uteri, - Basal cell carcinoma of the skin or localized squamous cell carcinoma of the skin, - Localized prostate cancer Gleason grade 6 or lower AND with stable prostate specific antigen (PSA) levels off treatment.
  • - Previous malignancy confined and surgically resected (or treated with other modalities) with curative intent.
  • - Known human immunodeficiency viral (HIV) infection.
  • - Active hepatitis B or C infection based on screening blood testing.
  • - Subject is receiving other ongoing anti-myeloma therapy.
  • - Subject has received any of the following within 7 days prior to the first dose of study drug: - Strong or moderate CYP3A inhibitors, or.
  • - Strong or moderate CYP3A inducers.
  • - Subject has received any of the following within 14 days prior to the first dose of study drug or has not recovered to less than a grade 2 clinically significant adverse effect(s)/toxicity(s) of the previous therapy: any anti-myeloma therapy including chemotherapy, radiotherapy, or investigational therapy, including targeted small molecule agents.
  • - Subject has received prior treatment with a BCL-2 family inhibitor.
  • - Subject is pregnant, parturient, or breastfeeding; deprived of freedom by judicial or administrative decision; hospitalized and unable to provide consent, or otherwise unable to provide consent.
  • - Subject has consumed grapefruit, grapefruit products, Seville oranges (including marmalade containing Seville oranges) or star fruit within 3 days prior to the first dose of study drug.
  • - Subject has received immunization with live vaccine within 60 days of dosing.
  • - Recent corticosteroid therapy at a cumulative dose equivalent to > 140 mg of prednisone or a single dose equivalent to >= 40 mg of dexamethasone within 2 weeks prior to the first dose of study drug.
- Subject's decision to not divulge the race

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT05391750
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 1
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Emory University
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Jonathan L. Kaufman, MD
Principal Investigator Affiliation Emory University
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Other, NIH
Overall Status Not yet recruiting
Countries United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma
Additional Details

PRIMARY OBJECTIVE:

  • I. To determine the dose limiting toxicity (DLT), safety profile, and the recommended phase 2 dose (RPTD) of venetoclax and tocilizumab when administered in subjects with relapsed and recurrent (RR) multiple myeloma t(11;14) (MM).
SECONDARY OBJECTIVES: I.To evaluate the preliminary efficacy data regarding the effect of venetoclax and tocilizumab by objective response rate per IMWG criteria.
  • II. To evaluate the effect of chronic tocilizumab administration on venetoclax exposure.
TERTIARY/EXPLORATORY OBJECTIVES:
  • I. To evaluate the preliminary efficacy data regarding the effect of venetoclax and tocilizumab by time to response (TTR), time to disease progression (TTP), duration of response (DOR), progression free survival (PFS) and overall survival (OS).
  • II. To measure the effect of IL6 receptor blockade on ex vivo venetoclax sensitivity.
  • III. To evaluate the cell populations in the bone marrow of responders versus non-responders as well as the effect of IL6 receptor blockade on those populations.
  • IV. To evaluate the expression of B cell markers on venetoclax sensitive myeloma.
  • V. To determine the expression of key BCL2 family members with and without IL6 receptor blockade.
  • VI. To correlate differences in somatic mutations, structural alterations, gene expression and chromatin accessibility with venetoclax response.
OUTLINE: This is a dose-escalation study of venetoclax and tocilizumab. Patients receive tocilizumab intravenously (IV) on day -7 of cycle 1, and on day 1 of subsequent cycles. Patients also receive venetoclax orally (PO) on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up for 4 weeks, then every 6 months thereafter.

Arms & Interventions

Arms

Experimental: Treatment (venetoclax, tocilizumab)

Patients receive tocilizumab IV on day -7 of cycle 1, and on day 1 of subsequent cycles. Patients also receive venetoclax PO on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Interventions

Biological: - Tocilizumab

Given IV

Drug: - Venetoclax

Given PO

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Atlanta, Georgia

Status

Address

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322

Site Contact

Bryan Burton

bjburto@emory.edu

404-778-1780