A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma

Study Purpose

The purpose of the study is to compare the efficacy of talquetamab subcutaneous(ly) (SC) in combination with daratumumab SC and pomalidomide (Tal-DP) and talquetamab SC in combination with daratumumab SC (Tal-D), respectively, with daratumumab in combination with pomalidomide and dexamethasone (DPd).

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Documented multiple myeloma as defined: a) Multiple myeloma diagnosis according to the International Myeloma Working Group (IMWG) diagnostic criteria and b) Measurable disease at screening as defined by any of the following: i) Serum M-protein level greater than or equal to (>=) 0.5 grams per deciliter (g/dL) (central laboratory); ii) Urine M-protein level >= 200 milligram (mg)/24 hours (central laboratory); iii) Light chain multiple myeloma without measurable M-protein in the serum or the urine: serum immunoglobulin free light chain >= 10 milligram per deciliter (mg/dL) (central laboratory), and abnormal serum immunoglobulin kappa lambda free light chain ratio.
  • - Relapsed or refractory disease as defined: a) Relapsed disease is defined as an initial response to prior treatment, followed by confirmed progressive disease by IMWG criteria greater than (>) 60 days after cessation of treatment; b) Refractory disease is defined as less than (<) 25 percent (%) reduction in monoclonal paraprotein (M-protein) or confirmed progressive disease by IMWG criteria during previous treatment or less than or equal to (=<) 60 days after cessation of treatment.
  • - Received at least 1 prior line of antimyeloma therapy including a proteasome inhibitor (PI) and lenalidomide.
Participants who have received only 1 prior line of antimyeloma therapy must be considered lenalidomide-refractory (that is, have demonstrated progressive disease by IMWG criteria on or within 60 days of completion of lenalidomide-containing regimen). Participants who have received >=2 prior lines of antimyeloma therapy must be considered lenalidomide exposed.
  • - Documented evidence of progressive disease based on investigator's determination of response by the IMWG criteria on or after their last regimen.
  • - Have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1, or 2 at screening and immediately prior to the start of administration of study treatment.

Exclusion Criteria:

  • - Contraindications or life-threatening allergies, hypersensitivity, or intolerance to study drug excipients.
  • - Disease is considered refractory to an anti-cluster of differentiation 38 (CD38) monoclonal antibody as defined per IMWG consensus guidelines (progression during treatment or within 60 days of completing therapy with an anti-CD38 monoclonal antibody) - A maximum cumulative dose of corticosteroids to >=140 milligrams (mg) of prednisone or equivalent within 14-day period before the first dose of study drug.
  • - Known active central nervous system (CNS) involvement or exhibits clinical signs of meningeal involvement of multiple myeloma.
If either is suspected, negative whole brain magnetic resonance imaging (MRI) and lumbar cytology are required. - Plasma cell leukemia at the time of screening, Waldenström's macroglobulinemia, polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS syndrome), or primary amyloid light chain amyloidosis

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT05455320
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Janssen Research & Development, LLC
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Janssen Research & Development, LLC Clinical Trial
Principal Investigator Affiliation Janssen Research & Development, LLC
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Belgium, Brazil, China, Czechia, France, Germany, Greece, Israel, Italy, Japan, Korea, Republic of, Netherlands, Poland, Spain, Taiwan, Turkey, United Kingdom, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Relapsed or Refractory Multiple Myeloma
Additional Details

Multiple myeloma is a malignant plasma cell disorder that accounts for approximately 10 percent (%) of all hematologic cancers, making it the second most common hematologic malignancy. Overall rationale of study is that combination treatments of talquetamab, daratumumab, pomalidomide and dexamethasone may lead to enhanced clinical responses in treatment of relapsed or refractory multiple myeloma through multiple mechanisms of action. The study is divided into 3 phases: screening, treatment (until confirmed progressive disease, death, intolerable toxicity, withdrawal of consent, or end of the study, whichever occurs first), and posttreatment follow-up (until death, withdrawal of consent, loss to follow-up, or end of the study, whichever occurs first). Efficacy, safety (physical examinations, neurologic examinations, Eastern Cooperative Oncology Group [ECOG] performance status, clinical laboratory tests, vital signs, and AE monitoring), pharmacokinetics (PK), immunogenicity, and biomarkers will be assessed at specified time points. Total duration of study will be up to 6 years 6 months.

Arms & Interventions

Arms

Experimental: Arm A: Talquetamab Subcutaneous (SC) in Combination With Daratumumab SC and Pomalidomide (Tal-DP)

Participants will receive talquetamab and daratumumab as SC injections; pomalidomide will be self-administered as a single dose orally; dexamethasone may be given orally or intravenously as a pretreatment medication.

Experimental: Arm B: Daratumumab in Combination With Pomalidomide and Dexamethasone (DPd)

Participants will receive daratumumab as SC injection; pomalidomide will be self-administered as a single dose orally; dexamethasone may be given orally or intravenously as a pretreatment medication.

Experimental: Arm C: Talquetamab SC in Combination With Daratumumab SC (Tal-D)

Participants will receive talquetamab and daratumumab as injection SC injection.

Interventions

Drug: - Talquetamab

Talquetamab will be administered subcutaneously.

Drug: - Daratumumab

Daratumumab will be administered subcutaneously.

Drug: - Pomalidomide

Pomalidomide will be administered orally.

Drug: - Dexamethasone

Dexamethasone will be administered orally or intravenously.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

The University of Arizona Cancer Center, Tucson, Arizona

Status

Not yet recruiting

Address

The University of Arizona Cancer Center

Tucson, Arizona, 85719

Little Rock, Arkansas

Status

Not yet recruiting

Address

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205

City of Hope, Duarte, California

Status

Withdrawn

Address

City of Hope

Duarte, California, 91010

University of California San Francisco, San Francisco, California

Status

Withdrawn

Address

University of California San Francisco

San Francisco, California, 94143

MedStar Georgetown University Hospital, Washington, District of Columbia

Status

Not yet recruiting

Address

MedStar Georgetown University Hospital

Washington, District of Columbia, 20007

University of Miami Health System, Miami, Florida

Status

Not yet recruiting

Address

University of Miami Health System

Miami, Florida, 33136

Grady Memorial Hospital, Atlanta, Georgia

Status

Withdrawn

Address

Grady Memorial Hospital

Atlanta, Georgia, 30303

University Of Illinois Medical Center, Chicago, Illinois

Status

Not yet recruiting

Address

University Of Illinois Medical Center

Chicago, Illinois, 60612

University of Kansas, Westwood, Kansas

Status

Not yet recruiting

Address

University of Kansas

Westwood, Kansas, 66205

Oschner Health System, New Orleans, Louisiana

Status

Not yet recruiting

Address

Oschner Health System

New Orleans, Louisiana, 70121-2429

University Of Maryland Medical Center, Baltimore, Maryland

Status

Not yet recruiting

Address

University Of Maryland Medical Center

Baltimore, Maryland, 21201

Massachusetts General, Boston, Massachusetts

Status

Not yet recruiting

Address

Massachusetts General

Boston, Massachusetts, 02114

Boston University Medical Center, Boston, Massachusetts

Status

Not yet recruiting

Address

Boston University Medical Center

Boston, Massachusetts, 02118

Worcester, Massachusetts

Status

Not yet recruiting

Address

University of Massachusetts Medical School

Worcester, Massachusetts, 01655

University of Michigan Health System, Ann Arbor, Michigan

Status

Not yet recruiting

Address

University of Michigan Health System

Ann Arbor, Michigan, 48109

University of Mississippi Medical Center, Jackson, Mississippi

Status

Not yet recruiting

Address

University of Mississippi Medical Center

Jackson, Mississippi, 39216

Washington University School of Medicine, Saint Louis, Missouri

Status

Not yet recruiting

Address

Washington University School of Medicine

Saint Louis, Missouri, 63110-1032

Roswell Park Cancer Institute, Buffalo, New York

Status

Not yet recruiting

Address

Roswell Park Cancer Institute

Buffalo, New York, 14263

NYU Langone Health, New York, New York

Status

Not yet recruiting

Address

NYU Langone Health

New York, New York, 10016

University of North Carolina, Chapel Hill, North Carolina

Status

Not yet recruiting

Address

University of North Carolina

Chapel Hill, North Carolina, 27599

Charlotte, North Carolina

Status

Not yet recruiting

Address

Levine Cancer Institute, Carolinas HealthCare System

Charlotte, North Carolina, 28204

Novant Health, Charlotte, North Carolina

Status

Withdrawn

Address

Novant Health

Charlotte, North Carolina, 28204

Cleveland, Ohio

Status

Not yet recruiting

Address

University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106

Columbus, Ohio

Status

Not yet recruiting

Address

The Ohio State University Wexner Medical Center - James Cancer Hospital

Columbus, Ohio, 43210

OhioHealth, Columbus, Ohio

Status

Not yet recruiting

Address

OhioHealth

Columbus, Ohio, 43214

Thomas Jefferson University, Philadelphia, Pennsylvania

Status

Not yet recruiting

Address

Thomas Jefferson University

Philadelphia, Pennsylvania, 19107-4215

Baptist Cancer Center, Memphis, Tennessee

Status

Not yet recruiting

Address

Baptist Cancer Center

Memphis, Tennessee, 38120

Dallas, Texas

Status

Not yet recruiting

Address

University of Texas Southwestern Medical Center

Dallas, Texas, 75390

Houston Methodist Hospital, Houston, Texas

Status

Not yet recruiting

Address

Houston Methodist Hospital

Houston, Texas, 77030

Richmond, Virginia

Status

Not yet recruiting

Address

Virginia Commonwealth University - Massey Cancer Center

Richmond, Virginia, 23219

Seattle Cancer Care Alliance, Seattle, Washington

Status

Not yet recruiting

Address

Seattle Cancer Care Alliance

Seattle, Washington, 98109

International Sites

UZ Brussel, Brussel, Belgium

Status

Recruiting

Address

UZ Brussel

Brussel, , 1090

UZA, Edegem, Belgium

Status

Not yet recruiting

Address

UZA

Edegem, , 2650

Virga Jessa Ziekenhuis, Hasselt, Belgium

Status

Not yet recruiting

Address

Virga Jessa Ziekenhuis

Hasselt, , 3500

CHC MontLegia, Liège, Belgium

Status

Not yet recruiting

Address

CHC MontLegia

Liège, , 4000

Clinique Saint Pierre, Ottignies, Belgium

Status

Not yet recruiting

Address

Clinique Saint Pierre

Ottignies, , 1340

UCL Mont Godinne, Yvoir, Belgium

Status

Not yet recruiting

Address

UCL Mont Godinne

Yvoir, , 5530

Brasilia, Brazil

Status

Not yet recruiting

Address

Hospitais Integradaos da Gavea S/A - DF Star

Brasilia, , 70390-140

Fundação Universidade de Caxias do Sul, Caxias do Sul, Brazil

Status

Not yet recruiting

Address

Fundação Universidade de Caxias do Sul

Caxias do Sul, , 95070 560

Curitiba, Brazil

Status

Not yet recruiting

Address

Hospital Erasto Gaertner- Liga Paranaense de Combate ao Câncer

Curitiba, , 81520-060

Centro de Pesquisas Oncológicas - CEPON, Florianópolis, Brazil

Status

Not yet recruiting

Address

Centro de Pesquisas Oncológicas - CEPON

Florianópolis, , 88034-000

Liga Norte Riograndense Contra O Cancer, Natal, Brazil

Status

Not yet recruiting

Address

Liga Norte Riograndense Contra O Cancer

Natal, , 59062-000

Porto Alegre, Brazil

Status

Not yet recruiting

Address

Irmandade Santa Casa de Misericordia de Porto Alegre

Porto Alegre, , 90050-170

Ribeirão Preto, Brazil

Status

Not yet recruiting

Address

Hospital das Clínicas da Faculdade de Medicina de RPUSP - HCRP

Ribeirão Preto, , 14051-140

Oncoclínicas Rio de Janeiro S.A., Rio de Janeiro, Brazil

Status

Not yet recruiting

Address

Oncoclínicas Rio de Janeiro S.A.

Rio de Janeiro, , 22250-905

Rio de Janeiro, Brazil

Status

Not yet recruiting

Address

Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI)

Rio de Janeiro, , 22793-080

Hospital Sao Rafael, Salvador, Brazil

Status

Not yet recruiting

Address

Hospital Sao Rafael

Salvador, , 41253-190

Instituto de Ensino e Pesquisa São Lucas, Sao Paulo, Brazil

Status

Not yet recruiting

Address

Instituto de Ensino e Pesquisa São Lucas

Sao Paulo, , 01236-030

Sao Paulo, Brazil

Status

Not yet recruiting

Address

Fundação Antônio Prudente - A.C. Camargo Cancer Center

Sao Paulo, , 01509900

São Paulo, Brazil

Status

Not yet recruiting

Address

Sociedade Beneficente de Senhoras - Hospital Sírio Libanês

São Paulo, , 01308-901

Hospital Paulistano, São Paulo, Brazil

Status

Not yet recruiting

Address

Hospital Paulistano

São Paulo, , 01321-001

Clinica Sao Germano, São Paulo, Brazil

Status

Not yet recruiting

Address

Clinica Sao Germano

São Paulo, , 01455-010

São Paulo, Brazil

Status

Not yet recruiting

Address

Instituto D'Or de Pesquisa e Ensino (IDOR)

São Paulo, , 4501000

Beijing Chaoyang Hospital, Beijing, China

Status

Not yet recruiting

Address

Beijing Chaoyang Hospital

Beijing, , 100020

Peking University First Hospital, Beijing, China

Status

Not yet recruiting

Address

Peking University First Hospital

Beijing, , 100034

The First Hospital of Jilin University, Changchun, China

Status

Not yet recruiting

Address

The First Hospital of Jilin University

Changchun, , 130021

Changsha, China

Status

Not yet recruiting

Address

The second Xiangya Hospital of Central South University

Changsha, , 410011

Chengdu, China

Status

Not yet recruiting

Address

Sichuan Academy of Medical Science Sichuan Provincial People's Hospital

Chengdu, , 610072

Chongqing, China

Status

Not yet recruiting

Address

Xinqiao Hospital. Army Medical University

Chongqing, , 400037

Fujian Medical University Union Hospital, Fuzhou, China

Status

Not yet recruiting

Address

Fujian Medical University Union Hospital

Fuzhou, , 350001

Sun Yat-Sen University Cancer Center, Guangzhou, China

Status

Not yet recruiting

Address

Sun Yat-Sen University Cancer Center

Guangzhou, , 510060

Guangdong Provincial People's Hospital, Guangzhou, China

Status

Not yet recruiting

Address

Guangdong Provincial People's Hospital

Guangzhou, , 510080

Hangzhou, China

Status

Not yet recruiting

Address

The First Affiliated Hospital, Zhejiang University College of Medicine

Hangzhou, , 310003

Nanjing Drum Tower Hospital, Nanjing, China

Status

Not yet recruiting

Address

Nanjing Drum Tower Hospital

Nanjing, , 210008

Tongji Hospital of Tongji University, Shanghai, China

Status

Not yet recruiting

Address

Tongji Hospital of Tongji University

Shanghai, , 200065

Peking University Shenzhen Hospital, Shenzhen, China

Status

Not yet recruiting

Address

Peking University Shenzhen Hospital

Shenzhen, , 518036

Su Zhou, China

Status

Not yet recruiting

Address

First Affiliated Hospital, SooChow University

Su Zhou, , 215006

Tianjin cancer hospital, Tianjin, China

Status

Not yet recruiting

Address

Tianjin cancer hospital

Tianjin, , 300060

Tianjin, China

Status

Not yet recruiting

Address

Institute of Hematology & Blood Disease Hospital Chinese Academy of Medical Science

Tianjin, , 300320

Wuhan, China

Status

Not yet recruiting

Address

Tongji Hospital, Tongji Medical College of HUST

Wuhan, , 430030

Xi' An, China

Status

Not yet recruiting

Address

The First Affiliated Hospital of Xi'an Jiaotong University

Xi' An, , 710061

Henan Cancer Hospital, Zhengzhou, China

Status

Not yet recruiting

Address

Henan Cancer Hospital

Zhengzhou, , 450008

Fakultni nemocnice Brno, Brno, Czechia

Status

Not yet recruiting

Address

Fakultni nemocnice Brno

Brno, , 625 00

Fakultni nemocnice Hradec Kralove, Hradec Kralove, Czechia

Status

Not yet recruiting

Address

Fakultni nemocnice Hradec Kralove

Hradec Kralove, , 500 05

Fakultní nemocnice Olomouc, Olomouc, Czechia

Status

Not yet recruiting

Address

Fakultní nemocnice Olomouc

Olomouc, , 779 00

Fakultni nemocnice Ostrava, Ostrava, Czechia

Status

Not yet recruiting

Address

Fakultni nemocnice Ostrava

Ostrava, , 70852

Fakultni nemocnice Kralovske Vinohrady, Praha 10, Czechia

Status

Not yet recruiting

Address

Fakultni nemocnice Kralovske Vinohrady

Praha 10, , 100 34

Praha 2, Czechia

Status

Not yet recruiting

Address

Vseobecna fakultni nemocnice v Praze - I. interni klinika - klinika hematologie

Praha 2, , 128 08

APHP - Hopital Henri Mondor, Creteil, France

Status

Not yet recruiting

Address

APHP - Hopital Henri Mondor

Creteil, , 94010

CHU Dijon, Dijon, France

Status

Not yet recruiting

Address

CHU Dijon

Dijon, , 21000

Centre Leon Bérard, Lyon, France

Status

Not yet recruiting

Address

Centre Leon Bérard

Lyon, , 69008

CHU de Montpellier - Hopital Saint-Eloi, Montpellier Cedex 5, France

Status

Not yet recruiting

Address

CHU de Montpellier - Hopital Saint-Eloi

Montpellier Cedex 5, , 34295

CHU de Nantes hôtel-Dieu, Nantes, France

Status

Not yet recruiting

Address

CHU de Nantes hôtel-Dieu

Nantes, , 44093

CHU HOPITAL DE L'ARCHET - Hematology, Nice N/a, France

Status

Not yet recruiting

Address

CHU HOPITAL DE L'ARCHET - Hematology

Nice N/a, , 06202

CHU Hôpital Saint Antoine, Paris Cedex 12, France

Status

Not yet recruiting

Address

CHU Hôpital Saint Antoine

Paris Cedex 12, , 75571

Pessac, France

Status

Not yet recruiting

Address

CHRU - Hôpital du Haut Lévêque - Centre François Magendie

Pessac, , 33604

Chu Rennes - Hopital Pontchaillou, Rennes, France

Status

Withdrawn

Address

Chu Rennes - Hopital Pontchaillou

Rennes, , 35000

TOULOUSE Cedex 9, France

Status

Not yet recruiting

Address

Institut Universitaire du cancer de Toulouse-Oncopole

TOULOUSE Cedex 9, , 31059

Charite Campus Benjamin Franklin, Berlin, Germany

Status

Not yet recruiting

Address

Charite Campus Benjamin Franklin

Berlin, , 12203

Universitatsklinikum Essen, Essen, Germany

Status

Withdrawn

Address

Universitatsklinikum Essen

Essen, , D-45147

Asklepios Klinik Altona, Hamburg, Germany

Status

Not yet recruiting

Address

Asklepios Klinik Altona

Hamburg, , 22763

Universitaetsklinikum Heidelberg, Heidelberg, Germany

Status

Not yet recruiting

Address

Universitaetsklinikum Heidelberg

Heidelberg, , 69120

Universitaetsklinikum Koeln, Koeln, Germany

Status

Not yet recruiting

Address

Universitaetsklinikum Koeln

Koeln, , 50937

Universitatsklinikum Leipzig, Leipzig, Germany

Status

Not yet recruiting

Address

Universitatsklinikum Leipzig

Leipzig, , 04103

Mainz, Germany

Status

Not yet recruiting

Address

Universitätsmedizin der Johannes Gutenberg Universität

Mainz, , 55131

Klinikum rechts der Isar der TU Munchen, Munchen, Germany

Status

Withdrawn

Address

Klinikum rechts der Isar der TU Munchen

Munchen, , 81675

Universitätsklinikum Würzburg, Würzburg, Germany

Status

Not yet recruiting

Address

Universitätsklinikum Würzburg

Würzburg, , 97080

Alexandra General Hospital of Athens, Athens Attica, Greece

Status

Not yet recruiting

Address

Alexandra General Hospital of Athens

Athens Attica, , 115 28

Athens, Greece

Status

Withdrawn

Address

University of Athens - Evaggelismos Hospital (Evangelismos Hospital)

Athens, , 106 76

Thessalonikis, Greece

Status

Not yet recruiting

Address

'G. Papanikolaou' Hospital of Thessaloniki

Thessalonikis, , 570 10

Thessaloniki, Greece

Status

Not yet recruiting

Address

Anticancer Hospital of Thessaloniki 'Theageneio'

Thessaloniki, , 546 39

Bnai Zion Medical Center, Haifa, Israel

Status

Not yet recruiting

Address

Bnai Zion Medical Center

Haifa, , 31048

Rambam Medical Center, Haifa, Israel

Status

Not yet recruiting

Address

Rambam Medical Center

Haifa, , 31096

Carmel Medical Center, Haifa, Israel

Status

Not yet recruiting

Address

Carmel Medical Center

Haifa, , 34362

Shaare Zedek Medical Center, Jerusalem, Israel

Status

Not yet recruiting

Address

Shaare Zedek Medical Center

Jerusalem, , 9103102

Hadassah Medical Center, Jerusalem, Israel

Status

Withdrawn

Address

Hadassah Medical Center

Jerusalem, , 91120

Galilee Medical Center, Nahariya, Israel

Status

Not yet recruiting

Address

Galilee Medical Center

Nahariya, , 22100

Beilinson medical center, Petah Tikva, Israel

Status

Not yet recruiting

Address

Beilinson medical center

Petah Tikva, , 49100

Sheba Medical Center, Ramat Gan, Israel

Status

Not yet recruiting

Address

Sheba Medical Center

Ramat Gan, , 52621

Ziv Medical Center, Safed, Israel

Status

Not yet recruiting

Address

Ziv Medical Center

Safed, , 13100

Sourasky (Ichilov) Medical Center, Tel Aviv, Israel

Status

Not yet recruiting

Address

Sourasky (Ichilov) Medical Center

Tel Aviv, , 6423906

Ancona, Italy

Status

Not yet recruiting

Address

A.O. Universitaria Ospedali Riuniti di Ancona

Ancona, , 60126

Policlinico di Bari, Bari, Italy

Status

Not yet recruiting

Address

Policlinico di Bari

Bari, , 70124

Bologna, Italy

Status

Not yet recruiting

Address

Azienda Ospedaliera Policlinico S. Orsola-Malpighi

Bologna, , 40138

Brescia, Italy

Status

Not yet recruiting

Address

Azienda Ospedaliera Spedali Civili di Brescia

Brescia, , 25123

Catania, Italy

Status

Not yet recruiting

Address

PO G.Rodolico, AOU Policlinico-Vittorio Emanuele Catania

Catania, , 95123

Milano, Italy

Status

Not yet recruiting

Address

Fondazione IRCCS Istituto Nazionale dei Tumori

Milano, , 20133

Milano, Italy

Status

Not yet recruiting

Address

ASST Grande Ospedale Metropolitano Niguarda

Milano, , 20162

Padova, Italy

Status

Not yet recruiting

Address

Azienda Ospedaliera Universitaria di Padova

Padova, , 35128

Ospedale Villa Sofia-Cervello, Palermo, Italy

Status

Not yet recruiting

Address

Ospedale Villa Sofia-Cervello

Palermo, , 90146

Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy

Status

Not yet recruiting

Address

Arcispedale Santa Maria Nuova - IRCCS

Reggio Emilia, , 42123

Roma, Italy

Status

Not yet recruiting

Address

Presidio Ospedaliero Santo Spirito in Sassia

Roma, , 00193

San Giovanni Rotondo, Italy

Status

Not yet recruiting

Address

IRCCS Ospedale Casa Sollievo della Sofferenza

San Giovanni Rotondo, , 71013

Torino, Italy

Status

Not yet recruiting

Address

A.O.U. Città della Salute e della Scienza

Torino, , 10126

Chiba Cancer Center, Chiba, Japan

Status

Not yet recruiting

Address

Chiba Cancer Center

Chiba, , 260-8717

Ogaki Municipal Hospital, Gifu, Japan

Status

Not yet recruiting

Address

Ogaki Municipal Hospital

Gifu, , 503-8502

Gunma University Hospital, Gunma, Japan

Status

Not yet recruiting

Address

Gunma University Hospital

Gunma, , 371-0034

Kansai Medical University Hospital, Hirakata, Japan

Status

Not yet recruiting

Address

Kansai Medical University Hospital

Hirakata, , 573-1191

Hyogo Medical University Hospital, Hyôgo, Japan

Status

Not yet recruiting

Address

Hyogo Medical University Hospital

Hyôgo, , 663-8501

Shonan Kamakura General Hospital, Kamakura-shi, Japan

Status

Not yet recruiting

Address

Shonan Kamakura General Hospital

Kamakura-shi, , 247-8533

National Cancer Center Hospital East, Kashiwa, Japan

Status

Not yet recruiting

Address

National Cancer Center Hospital East

Kashiwa, , 277-8577

Koshigaya, Japan

Status

Not yet recruiting

Address

Dokkyo Medical University Saitama Medical Center

Koshigaya, , 343-8555

Kumamoto University Hospital, Kumamoto, Japan

Status

Not yet recruiting

Address

Kumamoto University Hospital

Kumamoto, , 860-8556

Kyoto Kuramaguchi Medical Center, Kyoto, Japan

Status

Not yet recruiting

Address

Kyoto Kuramaguchi Medical Center

Kyoto, , 603-8151

Matsumoto, Japan

Status

Not yet recruiting

Address

National Hospital Organization Matsumoto Medical Center

Matsumoto, , 399-8701

Niigata Cancer Center Hospital, Niigata, Japan

Status

Not yet recruiting

Address

Niigata Cancer Center Hospital

Niigata, , 951-8566

Hokkaido University Hospital, Sapporo-shi, Japan

Status

Not yet recruiting

Address

Hokkaido University Hospital

Sapporo-shi, , 060-8648

Tohoku University Hospital, Sendai, Japan

Status

Not yet recruiting

Address

Tohoku University Hospital

Sendai, , 980-8574

Iwate Medical University Hospital, Shiwa-gun, Japan

Status

Not yet recruiting

Address

Iwate Medical University Hospital

Shiwa-gun, , 028-3695

Osaka University Hospital, Suita-shi, Japan

Status

Not yet recruiting

Address

Osaka University Hospital

Suita-shi, , 565-0871

The Cancer Institute Hospital of JFCR, Tokyo, Japan

Status

Not yet recruiting

Address

The Cancer Institute Hospital of JFCR

Tokyo, , 135-8550

Dong-A University Hospital, Busan, Korea, Republic of

Status

Not yet recruiting

Address

Dong-A University Hospital

Busan, , 602-812

National Cancer Center, Gyeonggi-do, Korea, Republic of

Status

Not yet recruiting

Address

National Cancer Center

Gyeonggi-do, , 10408

Gachon University Gil Medical Center, Incheon, Korea, Republic of

Status

Recruiting

Address

Gachon University Gil Medical Center

Incheon, , 21565

Jeollanam-do, Korea, Republic of

Status

Not yet recruiting

Address

Chonnam National University Hwasun Hospital

Jeollanam-do, , 58128

Jeonbuk National University Hospital, Jeonju-si, Korea, Republic of

Status

Not yet recruiting

Address

Jeonbuk National University Hospital

Jeonju-si, , 54907

Seoul National University Hospital, Seoul, Korea, Republic of

Status

Not yet recruiting

Address

Seoul National University Hospital

Seoul, , 03080

Seoul, Korea, Republic of

Status

Not yet recruiting

Address

Severance Hospital, Yonsei University Health System

Seoul, , 03722

Asan Medical Center, Seoul, Korea, Republic of

Status

Recruiting

Address

Asan Medical Center

Seoul, , 05505

Samsung Medical Center, Seoul, Korea, Republic of

Status

Not yet recruiting

Address

Samsung Medical Center

Seoul, , 06351

Seoul, Korea, Republic of

Status

Not yet recruiting

Address

The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, , 06591

Haga zkh, Den-Haag, Netherlands

Status

Withdrawn

Address

Haga zkh

Den-Haag, , 2545 CH

Dordrecht, Netherlands

Status

Not yet recruiting

Address

Albert Schweitzer ziekenhuis-lokatie Dordwijk

Dordrecht, , 3318 AT

Maxima Medisch Centrum, Eindhoven, Netherlands

Status

Not yet recruiting

Address

Maxima Medisch Centrum

Eindhoven, , 5631 BM

Maastricht University Medical Centre, Maastricht, Netherlands

Status

Not yet recruiting

Address

Maastricht University Medical Centre

Maastricht, , 6229 HX

Erasmus MC, Rotterdam, Netherlands

Status

Not yet recruiting

Address

Erasmus MC

Rotterdam, , 3015 CN

Brzozow, Poland

Status

Not yet recruiting

Address

Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza

Brzozow, , 36-200

Uniwersyteckie Centrum Kliniczne, Gdansk, Poland

Status

Not yet recruiting

Address

Uniwersyteckie Centrum Kliniczne

Gdansk, , 80-214

Pratia Onkologia Katowice, Katowice, Poland

Status

Recruiting

Address

Pratia Onkologia Katowice

Katowice, , 40-519

Kielce, Poland

Status

Recruiting

Address

Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach

Kielce, , 25-734

Szpital Uniwersytecki w Krakowie, Krakow, Poland

Status

Not yet recruiting

Address

Szpital Uniwersytecki w Krakowie

Krakow, , 31-501

Lublin, Poland

Status

Recruiting

Address

Centrum Onkologii Ziemi Lubelskiej im. św. Jana z Dukli

Lublin, , 20090

Olsztyn, Poland

Status

Not yet recruiting

Address

SP ZOZ MSWiA z Warmińsko-Mazurskim Centrum Onkologii w Olsztynie, Oddział Hematologii

Olsztyn, , 10-228

Warszawa, Poland

Status

Not yet recruiting

Address

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy

Warszawa, , 02-781

Wroclaw, Poland

Status

Not yet recruiting

Address

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu

Wroclaw, , 50-367

Hosp. Univ. Germans Trias I Pujol, Badalona, Spain

Status

Not yet recruiting

Address

Hosp. Univ. Germans Trias I Pujol

Badalona, , 08916

Hosp. Univ. Vall D Hebron, Barcelona, Spain

Status

Not yet recruiting

Address

Hosp. Univ. Vall D Hebron

Barcelona, , 08035

Hosp. Clinic I Provincial de Barcelona, Barcelona, Spain

Status

Not yet recruiting

Address

Hosp. Clinic I Provincial de Barcelona

Barcelona, , 08036

Hosp. de La Santa Creu I Sant Pau, Barcelona, Spain

Status

Not yet recruiting

Address

Hosp. de La Santa Creu I Sant Pau

Barcelona, , 08041

Hosp. Univ. Virgen de La Arrixaca, El Palmar, Murcia, Spain

Status

Not yet recruiting

Address

Hosp. Univ. Virgen de La Arrixaca

El Palmar, Murcia, , 30120

Hosp. de Jerez de La Frontera, Jerez de la Frontera, Spain

Status

Not yet recruiting

Address

Hosp. de Jerez de La Frontera

Jerez de la Frontera, , 11407

Hosp. de Leon, Leon, Spain

Status

Not yet recruiting

Address

Hosp. de Leon

Leon, , 24071

Hosp. Univ. de La Princesa, Madrid, Spain

Status

Not yet recruiting

Address

Hosp. Univ. de La Princesa

Madrid, , 28006

Hosp. Univ. 12 de Octubre, Madrid, Spain

Status

Not yet recruiting

Address

Hosp. Univ. 12 de Octubre

Madrid, , 28041

Hosp. Virgen de La Victoria, Malaga, Spain

Status

Not yet recruiting

Address

Hosp. Virgen de La Victoria

Malaga, , 29010

Hosp. Clinico Univ. de Salamanca, Salamanca, Spain

Status

Not yet recruiting

Address

Hosp. Clinico Univ. de Salamanca

Salamanca, , 37007

Hosp. Univ. de Canarias, San Cristóbal de La Laguna, Spain

Status

Not yet recruiting

Address

Hosp. Univ. de Canarias

San Cristóbal de La Laguna, , 38320

Hosp. Univ. Dr. Peset, Valencia, Spain

Status

Not yet recruiting

Address

Hosp. Univ. Dr. Peset

Valencia, , 46017

Kaohsiung, Taiwan

Status

Not yet recruiting

Address

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung, , 80756

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

Status

Not yet recruiting

Address

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung, , 83301

China Medical University Hospital, Taichung City, Taiwan

Status

Not yet recruiting

Address

China Medical University Hospital

Taichung City, , 40447

National Cheng Kung University Hospital, Tainan, Taiwan

Status

Recruiting

Address

National Cheng Kung University Hospital

Tainan, , 704

National Taiwan University Hospital, Taipei, Taiwan

Status

Not yet recruiting

Address

National Taiwan University Hospital

Taipei, , 10048

Taipei Veterans General Hospital, Taipei, Taiwan

Status

Not yet recruiting

Address

Taipei Veterans General Hospital

Taipei, , 112

Ankara, Turkey

Status

Not yet recruiting

Address

Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Hematology Unit

Ankara, , 06200

Ankara University Medical Faculty, Ankara, Turkey

Status

Not yet recruiting

Address

Ankara University Medical Faculty

Ankara, , 06590

Medipol Mega University Hospital, Istabul, Turkey

Status

Not yet recruiting

Address

Medipol Mega University Hospital

Istabul, , 34214

Istanbul, Turkey

Status

Not yet recruiting

Address

Istanbul University Istanbul Medical Faculty

Istanbul, , 34093

Dokuz Eylul University Medical Faculty, Izmir, Turkey

Status

Not yet recruiting

Address

Dokuz Eylul University Medical Faculty

Izmir, , 35330

Samsun, Turkey

Status

Not yet recruiting

Address

On Dokuz Mayıs University Medical Faculty

Samsun, , 55139

Blackpool Victoria Hospital, Blackpool, United Kingdom

Status

Not yet recruiting

Address

Blackpool Victoria Hospital

Blackpool, , FY3 8NR

Ninewells Hospital & Medical School, Dundee, United Kingdom

Status

Not yet recruiting

Address

Ninewells Hospital & Medical School

Dundee, , DD1 9SY

Newcastle Freeman Hospital, Newcastle Upon Tyne, United Kingdom

Status

Not yet recruiting

Address

Newcastle Freeman Hospital

Newcastle Upon Tyne, , NE7 7DN

Nottingham City Hospital, Nottingham, United Kingdom

Status

Not yet recruiting

Address

Nottingham City Hospital

Nottingham, , NG5 1PB

University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom

Status

Not yet recruiting

Address

University Hospitals Plymouth NHS Trust

Plymouth, , PL6 8DH

Royal Hallamshire Hospital, Sheffield, United Kingdom

Status

Not yet recruiting

Address

Royal Hallamshire Hospital

Sheffield, , S10 2JF

Royal Marsden Hospital, Sutton, United Kingdom

Status

Not yet recruiting

Address

Royal Marsden Hospital

Sutton, , SM2 5PT

New Cross Hospital, Wolverhampton, United Kingdom

Status

Not yet recruiting

Address

New Cross Hospital

Wolverhampton, , WV10 0QP