A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma

Study Purpose

The main purpose of the study is to evaluate the safety and tolerability of the combination of elranatamab and carfilzomib and dexamethasone or elranatamab and maplirpacept. There are 2 parts to this study. Part 1 will evaluate the safety and tolerability of elranatamab when given in combination with carfilzomib plus dexamethasone. Part 2 has 2 arms. The first will evaluate the safety and tolerability of elranatamab when given in combination with maplirpacept. The second will identify the optimal dose(s) of elranatamab plus maplirpacept. All study medicines are given over 4-week cycles. Everyone taking part in this study will receive elranatamab as a shot under the skin. Participants in Part 1 will also receive weekly carfilzomib as an IV infusion (given directly into a vein) and dexamethasone either by mouth (as a pill) or by IV infusion. Participants in Part 2 will receive elranatamab in combination with maplirpacept as an IV infusion (given directly into a vein) The investigators will examine the experiences of people receiving the study medicines. This will help determine if the study medicines are safe and can be used for multiple myeloma treatment. Participants will take part in this study for about 2 years after the first dose.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Prior diagnosis of multiple myeloma as defined by IMWG criteria.
  • - Measurable disease based on IMWG criteria as defined by at least 1 of the following: - Serum M-protein ≥0.5 g/dL.
  • - Urinary M-protein excretion ≥200 mg/24 hours.
  • - Serum immunoglobulin FLC ≥10 mg/dL (≥100 mg/L) AND abnormal serum immunoglobulin kappa to lambda FLC ratio (<0.26 or >1.65).
  • - Part 1: Received at least 1 but not more than 3 prior lines of therapy for multiple myeloma (induction therapy followed by stem cell transplant and consolidation/maintenance therapy will be considered as 1 line of therapy).
  • - Part 2: Received at least 3 prior lines of therapy for multiple myeloma who are refractory to at least one IMiD, one PI and one anti-CD38 antibody.
  • - ECOG performance status 0-1.
  • - Resolved acute effects of any prior therapy to baseline severity or CTCAE Grade ≤1.
  • - Not pregnant or breastfeeding and willing to use contraception.
  • - Prior therapy with carfilzomib is allowed as long as the participant had (all apply): responded to most recent therapy with carfilzomib; Carfilzomib was not discontinued due to toxicity; Did not relapse within 60 days from discontinuation of carfilzomib; Will have at least a 6-month carfilzomib treatment-free interval from last dose received until first study treatment.

Exclusion Criteria:

  • - Plasma cell leukemia, Smouldering MM, Waldenströms macroglobulinemia, Amyloidosis, POEMS Syndrome, Primary refractory MM.
  • - Impaired cardiovascular function or clinically significant cardiovascular diseases.
  • - Participants with any active, uncontrolled bacterial, fungal, or viral infection.
  • - Stem cell transplant within 12 weeks prior to enrollment, or active graft versus host disease.
  • - Any other active malignancy within 3 years prior to enrollment, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ.
  • - Part 1: Previous treatment with a BCMA-directed therapy.
  • - Part 2: Previous treatment with any anti-BCMA directed therapy, with the exception of CAR-T.
Previous treatment with a CD47-SIRP alpha-directed therapy.
  • - Live attenuated vaccine within 4 weeks of the first dose of study intervention.
  • - Administration with an investigational product (e.g. drug or vaccine) concurrent with study intervention or within 30 days preceding the first dose of study intervention used in this study.
  • - Any of the following within 3 months of enrollment: erosive esophagitis, treatment resistant peptic ulcer, infectious or inflammatory bowel disease, pulmonary embolism or uncontrolled thromboembolic event.
  • - Participants who are unable to tolerate carfilzomib due to suspected carfilzomib-related congestive heart failure or thrombotic microangiopathy.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT05675449
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 1
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Pfizer
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Pfizer CT.gov Call Center
Principal Investigator Affiliation Pfizer
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Israel, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Multiple Myeloma
Study Website: View Trial Website
Arms & Interventions

Arms

Experimental: Part 1 Dose Escalation

Non randomized Elranatamab plus Carfilzomib and Dexamethasone

Experimental: Part 2A Dose Escalation

Non randomized Elranatamab plus Maplirpacept

Experimental: Part 2B Dose Randomization

Randomized dose level Elranatamab plus Maplirpacept

Interventions

Drug: - Elranatamab

BCMA-CD3 bispecific antibody

Drug: - Carfilzomib

proteasome inhibitor

Drug: - Maplirpacept

CD47-SIRP alpha-directed

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Little Rock, Arkansas

Status

Not yet recruiting

Address

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205

Beverly Hills Cancer Center, Beverly Hills, California

Status

Recruiting

Address

Beverly Hills Cancer Center

Beverly Hills, California, 90211

Aventura, Florida

Status

Recruiting

Address

Sylvester Comprehensive Cancer Center - Aventura

Aventura, Florida, 33180

Coral Gables, Florida

Status

Recruiting

Address

Sylvester Comprehensive Cancer Center- The Lennar Foundation Medical Center

Coral Gables, Florida, 33146

Coral Springs, Florida

Status

Recruiting

Address

Sylvester Comprehensive Cancer Center - Coral Springs

Coral Springs, Florida, 33065

Deerfield Beach, Florida

Status

Recruiting

Address

University of Miami Hospital and Clinics - Deerfield Beach

Deerfield Beach, Florida, 33442

Hollywood, Florida

Status

Recruiting

Address

Sylvester Comprehensive Cancer Center - Hollywood

Hollywood, Florida, 33021

Sylvester Comprehensive Cancer Center, Miami, Florida

Status

Recruiting

Address

Sylvester Comprehensive Cancer Center

Miami, Florida, 33136

University of Miami Hospital And Clinics, Miami, Florida

Status

Recruiting

Address

University of Miami Hospital And Clinics

Miami, Florida, 33136

Miami, Florida

Status

Recruiting

Address

Sylvester Comprehensive Cancer Center - Kendall

Miami, Florida, 33176

Plantation, Florida

Status

Recruiting

Address

Sylvester Comprehensive Cancer Center - Plantation

Plantation, Florida, 33324

Emory University Hospital Midtown, Atlanta, Georgia

Status

Not yet recruiting

Address

Emory University Hospital Midtown

Atlanta, Georgia, 30308

Emory University Hospital, Atlanta, Georgia

Status

Not yet recruiting

Address

Emory University Hospital

Atlanta, Georgia, 30322

Winship Cancer Institute, Atlanta, Georgia

Status

Not yet recruiting

Address

Winship Cancer Institute

Atlanta, Georgia, 30322

University of Iowa Hospitals and Clinics, Iowa City, Iowa

Status

Recruiting

Address

University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242

Baltimore, Maryland

Status

Recruiting

Address

Oncology Investigational Drug Service,Department of Pharmacy Services

Baltimore, Maryland, 21231

Baltimore, Maryland

Status

Recruiting

Address

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, Maryland, 21231

Johns Hopkins Medicine, Baltimore, Maryland

Status

Recruiting

Address

Johns Hopkins Medicine

Baltimore, Maryland, 21287

Massachusetts General Hospital, Boston, Massachusetts

Status

Recruiting

Address

Massachusetts General Hospital

Boston, Massachusetts, 02114

New York, New York

Status

Not yet recruiting

Address

Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).

New York, New York, 10021

New York, New York

Status

Not yet recruiting

Address

Memorial Sloan Kettering Cancer Center - Main Campus

New York, New York, 10065

International Sites

Rambam Health Care Campus, Haifa, Israel

Status

Not yet recruiting

Address

Rambam Health Care Campus

Haifa, , 3109601

Jerusalem, Israel

Status

Recruiting

Address

Division of Hematology Hadassah Medical Center - Ein Kerem

Jerusalem, , 9112001

Hadassah Medical Center - Ein Kerem, Jerusalem, Israel

Status

Recruiting

Address

Hadassah Medical Center - Ein Kerem

Jerusalem, , 9112001

Petach Tikvah, Israel

Status

Not yet recruiting

Address

Hematology Division Davidoff Center, Rabin Medical Center, Bellinson Hospital

Petach Tikvah, , 4941494

Petah Tikva, Israel

Status

Not yet recruiting

Address

Hematology Division Davidoff Center, Rabin Medical Center, Beilinson Hospital

Petah Tikva, , 4941492

Petah Tikva, Israel

Status

Not yet recruiting

Address

Hematology Division Davidoff Center, Rabin Medical Center, Beilinson Hospital

Petah Tikva, , 4941494

The Chaim Sheba Medical Center, Ramat-Gan, Israel

Status

Not yet recruiting

Address

The Chaim Sheba Medical Center

Ramat-Gan, , 5265601

Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel

Status

Not yet recruiting

Address

Tel-Aviv Sourasky Medical Center

Tel Aviv, , 6423906