Inclusion Criteria:
1. Patients must be aged ≥18 years to 80 years old.
2. Patients must have received three prior lines of therapies, including proteasome
inhibitor, immunomodulator and a cluster of differentiation (CD) 38 monoclonal
antibody:
• International Myeloma Working Group (IMWG) criteria defines refractory disease as
disease progression on or within 60 days of receiving therapy.
3. Patients must have measurable disease, including at least one or more of the following
criteria:
1. Serum M-protein ≥0.5 g/dl;
2. Urine M-protein ≥200 mg/24 hrs;
3. Involved serum light chain ≥100 mg/L with abnormal light chain ratio;
4. Absolute CD 3 count ≥50 mm^3.
5. Karnofsky performance score ≥70.
6. Adequate hepatic function, defined as:
1. aspartate aminotransferase (AST), alanine transaminase (ALT), and alkaline
phosphatase <3x upper limit of normal (ULN);
2. Serum bilirubin <2.0 mg/dL except for patients with Gilbert's syndrome, who must
have serum bilirubin of <3 mg/dL.
7. Absolute neutrophil count (ANC) ≥1,000 with no Granulocyte colony-stimulating factor
(G-CSF) within 72 hours or pegylated G-CSF within 10 days.
8. Platelets ≥50,000/µL with no transfusion within 72 hours of eligibility testing.
9. Adequate renal function, defined as creatinine clearance ≥50 mL/min calculated using
the Cockroft-Gault formula.
10. Able to provide written informed consent.
11. Agree to practice birth control during the study.
12. Adequate cardiac function as indicated by New York Heart Association (NYHA)
classification I or II AND left ventricular ejection fraction of ≥45% (by cardiac
echocardiogram (ECHO) or multigated acquisition (MUGA)) and adequate pulmonary
function as indicated by room air oxygen saturation of ≥90%.
13. Expected survival >12 weeks.
14. Negative urine or serum pregnancy test in females of childbearing potential at study
entry.
15. Meet criteria for regarding fertility and contraception detailed below.
16. No contraindication to central line access.
Phase I Dose-Expansion Cohort A: BCMA Naïve The inclusion criteria for dose-expansion
Cohort A are the same as that listed above but are limited to BCMA naïve patients.
Phase I Dose-Expansion Cohort B: BCMA Exposed The inclusion criteria for dose expansion
Cohort B are the same as that above but require prior exposure to BCMA directed therapies
(e.g., CAR-BCMA, bispecific T/ Natural Killer (NK) cell engagers of BCMA).
Patients with prior antibody drug conjugate, bispecific T and NK cell engager and prior
gene-modified cellular immune therapy against BCMA are allowed. Patients must be > 3 months
out from therapy and must have achieved stable disease or better with prior BCMA-directed
therapy.
Exclusion Criteria:
1. Positive beta- Human chorionic gonadotropin (HCG) in female of child-bearing potential
defined as per the Schedule of Events table.
2. Confirmed active human immunodeficiency virus (HIV), Hepatitis B or C infection.
3. History of significant autoimmune disease OR active, uncontrolled autoimmune
phenomenon requiring steroid therapy defined as >20 mg of prednisone or equivalent
daily.
4. Presence of ≥ Grade 3 non-hematologic toxicities as per CTCAE version 5.0 from any
previous treatment unless it is felt to be due to underlying disease.
5. Concurrent use of investigational therapeutic agents or enrollment on another
therapeutic clinical trial at any institution. Minimum of 14 days or 5 half-lives of
the drug (whichever is shorter) washout prior to apheresis.
6. Refusal to participate in the long-term follow-up protocol.
7. Patients with active central nervous system (CNS) involvement by malignancy on MRI or
by lumbar puncture.
a. Patients with prior CNS disease that has been effectively treated will be eligible
providing last treatment was ≥2 weeks before apheresis and a remission documented
within 4 weeks of planned CAR T-cell infusion by MRI brain and CSF analysis.
8. Previous recipients of allogeneic hematopoietic stem cell transplantation (AHCT) are
excluded if they are <6 months post-transplant, have evidence of active
graft-versus-host-disease (GVHD) of any grade, or are currently on immunosuppression.
9. Plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS syndrome, and AL
amyloidosis.
10. Prior treatment with gene therapy or any gene modified cellular therapy (only
permitted in cohort B for the dose expansion phase).
11. Prior BCMA-directed therapy (only permitted in cohort B for the dose expansion phase).
12. Cytotoxic chemotherapy, oral chemotherapeutic agents, or antibody-directed treatment
within 14 days of apheresis or after apheresis.
1. Corticosteroids are allowable up until 7 days prior to apheresis and after
apheresis for disease control up until the day prior to cell infusion (Day -1).
2. Radiation is allowed to a single symptomatic site.
13. Patients post solid organ transplant who develop high grade lymphomas or leukemias.
14. Concurrent active malignancy other than basal or squamous cell carcinomas of the skin.
15. Active bacterial, viral, or fungal infection requiring systemic treatment.
16. Patients who have received major surgery 1 week prior to leukapheresis and 3 weeks
prior to lymphodepletion.
17. Active malignancy that required therapy in the last 2 years except successfully
treated non metastatic basal or squamous cell carcinoma, or prostate carcinoma that
does not require therapy. Other similar conditions may be discussed with and permitted
by the medical monitor.
Special Criteria Regarding Fertility and Contraception. Female subjects of reproductive potential (women who have reached menarche or women who
have not been post-menopausal for at least 24 consecutive months, i.e., who have had menses
within the preceding 24 months, or have not undergone a sterilization procedure
[hysterectomy or bilateral oophorectomy]) must have a negative serum or urine pregnancy
test performed as part of eligibility criteria. Lactating women are eligible for this study
but will be asked to not provide breast milk to their child from Day -4 through Day +90
after CAR T-cell therapy.
Due to the high-risk level of this study, while enrolled, all subjects must agree not to
participate in a conception process (e.g., active attempt to become pregnant or to
impregnate, sperm donation, in vitro fertilization). Additionally, if participating in
sexual activity that could lead to pregnancy, the study subject must agree to use reliable
and double barrier methods of contraception during the follow-up period of the protocol.
Acceptable birth control includes a combination of two of the following methods:
- - Condoms (male or female) with or without a spermicidal agent.
- - Diaphragm or cervical cap with spermicide.
- - Intrauterine device (IUD).
- - Hormonal-based contraception.
Subjects who are not of reproductive potential (women
who are premenarche or have been post-menopausal for at least 24 consecutive months or
have undergone hysterectomy, tubal ligation, salpingectomy, and/or bilateral
oophorectomy or men who have documented azoospermia) are eligible without requiring
the use of contraception.
